FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023443387> ?p ?o ?g. }

• W2023443387 endingPage "e45352" @default.
• W2023443387 startingPage "e45352" @default.
• W2023443387 abstract "Oxysterol-binding protein (OSBP) homologues, ORPs, are implicated in lipid homeostatic control, vesicle transport, and cell signaling. We analyzed here the quantity of ORP mRNAs in human subcutaneous (s.c.) and visceral adipose depots, as well as in the Simpson-Golabi-Behmel syndrome (SGBS) adipocyte cell model. All of the ORP mRNAs were present in the s.c and visceral adipose tissues, and the two depots shared an almost identical ORP mRNA expression pattern. SGBS adipocytes displayed a similar pattern, suggesting that the adipose tissue ORP expression pattern mainly derives from adipocytes. During SGBS cell adipogenic differentiation, ORP2, ORP3, ORP4, ORP7, and ORP8 mRNAs were down-regulated, while ORP11 was induced. To assess the impacts of ORPs on adipocyte differentiation, ORP3 and ORP8, proteins down-regulated during adipogenesis, were overexpressed in differentiating SGBS adipocytes, while ORP11, a protein induced during adipogenesis, was silenced. ORP8 overexpression resulted in reduced expression of the aP2 mRNA, while down-regulation of adiponectin and aP2 was observed in ORP11 silenced cells. Furthermore, ORP8 overexpression or silencing of ORP11 markedly decreased cellular triglyceride storage. These data identify the patterns of ORP expression in human adipose depots and SGBS adipocytes, and provide the first evidence for a functional impact of ORPs on the adipocyte phenotype." @default.
• W2023443387 created "2016-06-24" @default.
• W2023443387 creator A5003315497 @default.
• W2023443387 creator A5024839047 @default.
• W2023443387 creator A5028953583 @default.
• W2023443387 creator A5043534256 @default.
• W2023443387 creator A5059226611 @default.
• W2023443387 creator A5075525029 @default.
• W2023443387 creator A5080964919 @default.
• W2023443387 creator A5089547723 @default.
• W2023443387 date "2012-09-21" @default.
• W2023443387 modified "2023-10-16" @default.
• W2023443387 title "OSBP-Related Proteins (ORPs) in Human Adipose Depots and Cultured Adipocytes: Evidence for Impacts on the Adipocyte Phenotype" @default.
• W2023443387 cites W1543877671 @default.
• W2023443387 cites W1911203599 @default.
• W2023443387 cites W1968771604 @default.
• W2023443387 cites W1971681081 @default.
• W2023443387 cites W1979026271 @default.
• W2023443387 cites W1980978820 @default.
• W2023443387 cites W1993083084 @default.
• W2023443387 cites W1996878278 @default.
• W2023443387 cites W2003882200 @default.
• W2023443387 cites W2009590767 @default.
• W2023443387 cites W2010903584 @default.
• W2023443387 cites W2011123221 @default.
• W2023443387 cites W2011972906 @default.
• W2023443387 cites W2012859794 @default.
• W2023443387 cites W2015964534 @default.
• W2023443387 cites W2017506227 @default.
• W2023443387 cites W2021843879 @default.
• W2023443387 cites W2025590812 @default.
• W2023443387 cites W2026957990 @default.
• W2023443387 cites W2029226240 @default.
• W2023443387 cites W2030324011 @default.
• W2023443387 cites W2031881762 @default.
• W2023443387 cites W2036468147 @default.
• W2023443387 cites W2038756684 @default.
• W2023443387 cites W2038959189 @default.
• W2023443387 cites W2040429499 @default.
• W2023443387 cites W2042107619 @default.
• W2023443387 cites W2042942930 @default.
• W2023443387 cites W2050373296 @default.
• W2023443387 cites W2051676732 @default.
• W2023443387 cites W2056142181 @default.
• W2023443387 cites W2061346606 @default.
• W2023443387 cites W2063706408 @default.
• W2023443387 cites W2064892346 @default.
• W2023443387 cites W2075496997 @default.
• W2023443387 cites W2075962801 @default.
• W2023443387 cites W2081705352 @default.
• W2023443387 cites W2083351001 @default.
• W2023443387 cites W2084248110 @default.
• W2023443387 cites W2090482031 @default.
• W2023443387 cites W2093456578 @default.
• W2023443387 cites W2097456275 @default.
• W2023443387 cites W2099410699 @default.
• W2023443387 cites W2104085328 @default.
• W2023443387 cites W2112283367 @default.
• W2023443387 cites W2112837303 @default.
• W2023443387 cites W2113570079 @default.
• W2023443387 cites W2129646574 @default.
• W2023443387 cites W2131765400 @default.
• W2023443387 cites W2134303620 @default.
• W2023443387 cites W2136495309 @default.
• W2023443387 cites W2137218769 @default.
• W2023443387 cites W2141541638 @default.
• W2023443387 cites W2152221138 @default.
• W2023443387 cites W2159756099 @default.
• W2023443387 cites W2169265393 @default.
• W2023443387 cites W2170914659 @default.
• W2023443387 cites W2171781845 @default.
• W2023443387 cites W2188496307 @default.
• W2023443387 cites W2215629512 @default.
• W2023443387 doi "https://doi.org/10.1371/journal.pone.0045352" @default.
• W2023443387 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3448648" @default.
• W2023443387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23028956" @default.
• W2023443387 hasPublicationYear "2012" @default.
• W2023443387 type Work @default.
• W2023443387 sameAs 2023443387 @default.
• W2023443387 citedByCount "22" @default.
• W2023443387 countsByYear W20234433872013 @default.
• W2023443387 countsByYear W20234433872015 @default.
• W2023443387 countsByYear W20234433872016 @default.
• W2023443387 countsByYear W20234433872017 @default.
• W2023443387 countsByYear W20234433872018 @default.
• W2023443387 countsByYear W20234433872020 @default.
• W2023443387 countsByYear W20234433872021 @default.
• W2023443387 countsByYear W20234433872022 @default.
• W2023443387 countsByYear W20234433872023 @default.
• W2023443387 crossrefType "journal-article" @default.
• W2023443387 hasAuthorship W2023443387A5003315497 @default.
• W2023443387 hasAuthorship W2023443387A5024839047 @default.
• W2023443387 hasAuthorship W2023443387A5028953583 @default.
• W2023443387 hasAuthorship W2023443387A5043534256 @default.
• W2023443387 hasAuthorship W2023443387A5059226611 @default.
• W2023443387 hasAuthorship W2023443387A5075525029 @default.
• W2023443387 hasAuthorship W2023443387A5080964919 @default.
• W2023443387 hasAuthorship W2023443387A5089547723 @default.

• next