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• W2023443417 abstract "The mechanisms for the establishment and maintenance of cell polarity in neurons are not well understood. Axon regeneration from dendrites has been reported after axotomy near the cell body in vivo. We report here in vitro a reversal of neuronal polarity characterized by the conversion of dendrites into axons. We isolated neurons from the neonatal rat cerebral cortex. Neurons that exhibited an apical dendrite with a length of >100 μm were monitored for 3 days in culture. In 66% of neurons examined, a new axon, as identified by reactivity with an antibody to dephosphorylated tau or by lack of reactivity with an antibody to the a and b isoforms of microtubule-associated protein 2, appeared to form from the tip of the original dendrite. Further analysis of such neurons revealed that the distal half of the original dendrite became positive for dephosphorylated tau or negative for microtubule-associated protein 2. Time-lapse video microscopy demonstrated the conversion of the original dendrite into an axon without dendritic retraction. Axon regeneration from dendritic tips required a significantly longer time than axon regeneration from minor processes. Our observations thus demonstrate in vitro a time-consuming reversal of neuronal polarity and the conversion of a dendritic cytoskeleton into an axonal one." @default.
• W2023443417 created "2016-06-24" @default.
• W2023443417 creator A5062216474 @default.
• W2023443417 creator A5072374785 @default.
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• W2023443417 date "2002-03-01" @default.
• W2023443417 modified "2023-09-30" @default.
• W2023443417 title "Reversal of neuronal polarity characterized by conversion of dendrites into axons in neonatal rat cortical neurons in vitro" @default.
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• W2023443417 doi "https://doi.org/10.1016/s0306-4522(01)00592-9" @default.
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