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- W2023443497 abstract "α-Methyl-5-hydroxytryptophan was shown to exert a releasing action on mouse heart 3H-norepinephrine and endogenous norepinephrine. This releasing action was blocked by pretreatment with m-cresol, α-(1-methylhydrazino)-dihydrogen phosphate (50 mg/kg), a decarboxylase inhibitor, and the releasing action was therefore attributed to the decarboxylation product, α-methyl-5-hydroxytryptamine. α-Methyl-5-hydroxytryptamine (15 mg/kg) was found to deplete heart norepinephrine to 30 per cent of control levels after 8 hr, which was as great a depletion as that obtained with α-methyl-5-hydroxytryptophan (200 mg/kg) after a similar time period. The duration of action of the two compounds was also comparable, norepinephrine returning to approximately 50 per cent of control values in 24 hr. α-Methyl-5-hydroxytryptamine was identified chromatographically in mouse hearts pretreated with α-rnethyl-5-hydroxytryptophan." @default.
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- W2023443497 date "1969-07-01" @default.
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- W2023443497 title "Effects of α-methyl-5-hydroxytryptophan and α-methyl-5-hydroxytryptamine on norepinephrine in mouse myocardium" @default.
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- W2023443497 doi "https://doi.org/10.1016/0006-2952(69)90147-6" @default.
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