FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023444235> ?p ?o ?g. }

• W2023444235 endingPage "32" @default.
• W2023444235 startingPage "25" @default.
• W2023444235 abstract "The selective toxicity of anticancer drugs can be improved with the use of antibody-targeted liposomes. We hypothesize that liposomes targeted via antibodies against two or more receptor populations will increase the apparent receptor density on the target cells, resulting in improved therapeutic affects. A fluorescent assay was developed, using the fluorophores Alexa Fluor 350 and 532 to label monoclonal antibodies (mAb), and used to quantitate two different mAb populations coupled to the same liposome surface to within +/-10% of the values obtained with radiolabeled antibody (125I) tracers. The binding and uptake of targeted liposomes by B lymphoma (Namalwa) cells were examined for either individual populations of alphaCD19-targeted or alphaCD20-targeted liposomes, mixed populations (1:1) of alphaCD19-targeted liposomes plus alphaCD20-targeted liposomes, and dual-targeted liposomes, i.e., equal amount of both alphaCD19 and alphaCD20 on the same liposomes. At similar antibody densities, the binding and uptake of the dual-targeted liposomes were greater than that of either individually targeted liposomes alone, and showed additivity. At the same total lipid and antibody densities, 1:1 mixtures of individually targeted liposomes gave similar results to dual-targeted liposomes. Cytotoxicity was also improved, with DXR-loaded dual-targeted liposomes appearing to have higher cytotoxicity than 1:1 mixtures of individually targeted liposomes." @default.
• W2023444235 created "2016-06-24" @default.
• W2023444235 creator A5001472356 @default.
• W2023444235 creator A5016652732 @default.
• W2023444235 creator A5085614796 @default.
• W2023444235 date "2005-06-01" @default.
• W2023444235 modified "2023-09-27" @default.
• W2023444235 title "Liposomes targeted via two different antibodies: Assay, B-cell binding and cytotoxicity" @default.
• W2023444235 cites W1584408652 @default.
• W2023444235 cites W1971983208 @default.
• W2023444235 cites W1983671192 @default.
• W2023444235 cites W1994684937 @default.
• W2023444235 cites W2002516695 @default.
• W2023444235 cites W2013470095 @default.
• W2023444235 cites W2025919388 @default.
• W2023444235 cites W2039350685 @default.
• W2023444235 cites W2041759339 @default.
• W2023444235 cites W2042975268 @default.
• W2023444235 cites W2061382418 @default.
• W2023444235 cites W2076941870 @default.
• W2023444235 cites W2114918609 @default.
• W2023444235 cites W2140250503 @default.
• W2023444235 cites W2172105255 @default.
• W2023444235 doi "https://doi.org/10.1016/j.bbamem.2005.02.007" @default.
• W2023444235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15904660" @default.
• W2023444235 hasPublicationYear "2005" @default.
• W2023444235 type Work @default.
• W2023444235 sameAs 2023444235 @default.
• W2023444235 citedByCount "100" @default.
• W2023444235 countsByYear W20234442352012 @default.
• W2023444235 countsByYear W20234442352013 @default.
• W2023444235 countsByYear W20234442352014 @default.
• W2023444235 countsByYear W20234442352015 @default.
• W2023444235 countsByYear W20234442352016 @default.
• W2023444235 countsByYear W20234442352017 @default.
• W2023444235 countsByYear W20234442352018 @default.
• W2023444235 countsByYear W20234442352019 @default.
• W2023444235 countsByYear W20234442352020 @default.
• W2023444235 countsByYear W20234442352021 @default.
• W2023444235 countsByYear W20234442352022 @default.
• W2023444235 countsByYear W20234442352023 @default.
• W2023444235 crossrefType "journal-article" @default.
• W2023444235 hasAuthorship W2023444235A5001472356 @default.
• W2023444235 hasAuthorship W2023444235A5016652732 @default.
• W2023444235 hasAuthorship W2023444235A5085614796 @default.
• W2023444235 hasConcept C109316439 @default.
• W2023444235 hasConcept C121332964 @default.
• W2023444235 hasConcept C121608353 @default.
• W2023444235 hasConcept C126511603 @default.
• W2023444235 hasConcept C153911025 @default.
• W2023444235 hasConcept C159654299 @default.
• W2023444235 hasConcept C185154212 @default.
• W2023444235 hasConcept C185592680 @default.
• W2023444235 hasConcept C202751555 @default.
• W2023444235 hasConcept C203014093 @default.
• W2023444235 hasConcept C2776759294 @default.
• W2023444235 hasConcept C2780035454 @default.
• W2023444235 hasConcept C2781230642 @default.
• W2023444235 hasConcept C542903549 @default.
• W2023444235 hasConcept C54355233 @default.
• W2023444235 hasConcept C55493867 @default.
• W2023444235 hasConcept C62520636 @default.
• W2023444235 hasConcept C86803240 @default.
• W2023444235 hasConcept C91881484 @default.
• W2023444235 hasConcept C98274493 @default.
• W2023444235 hasConceptScore W2023444235C109316439 @default.
• W2023444235 hasConceptScore W2023444235C121332964 @default.
• W2023444235 hasConceptScore W2023444235C121608353 @default.
• W2023444235 hasConceptScore W2023444235C126511603 @default.
• W2023444235 hasConceptScore W2023444235C153911025 @default.
• W2023444235 hasConceptScore W2023444235C159654299 @default.
• W2023444235 hasConceptScore W2023444235C185154212 @default.
• W2023444235 hasConceptScore W2023444235C185592680 @default.
• W2023444235 hasConceptScore W2023444235C202751555 @default.
• W2023444235 hasConceptScore W2023444235C203014093 @default.
• W2023444235 hasConceptScore W2023444235C2776759294 @default.
• W2023444235 hasConceptScore W2023444235C2780035454 @default.
• W2023444235 hasConceptScore W2023444235C2781230642 @default.
• W2023444235 hasConceptScore W2023444235C542903549 @default.
• W2023444235 hasConceptScore W2023444235C54355233 @default.
• W2023444235 hasConceptScore W2023444235C55493867 @default.
• W2023444235 hasConceptScore W2023444235C62520636 @default.
• W2023444235 hasConceptScore W2023444235C86803240 @default.
• W2023444235 hasConceptScore W2023444235C91881484 @default.
• W2023444235 hasConceptScore W2023444235C98274493 @default.
• W2023444235 hasIssue "1" @default.
• W2023444235 hasLocation W20234442351 @default.
• W2023444235 hasLocation W20234442352 @default.
• W2023444235 hasOpenAccess W2023444235 @default.
• W2023444235 hasPrimaryLocation W20234442351 @default.
• W2023444235 hasRelatedWork W1612226940 @default.
• W2023444235 hasRelatedWork W1973692620 @default.
• W2023444235 hasRelatedWork W1992169430 @default.
• W2023444235 hasRelatedWork W2009889818 @default.
• W2023444235 hasRelatedWork W2023444235 @default.
• W2023444235 hasRelatedWork W2067077431 @default.
• W2023444235 hasRelatedWork W2122854061 @default.
• W2023444235 hasRelatedWork W2368460920 @default.

• next