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• W2023444440 abstract "Today many SCI patients are surviving long enough to develop age-related diseases such as AAA. In a consecutive series, 9% of male veteran chronic SCI patients were found to have previously unrecognized AAAs. Resting aortic hemodynamic conditions, as determined by MRA and PC-MRI, were markedly abnormal in SCI patients, characterized by reduced retrograde flow in diastole, reduced oscillatory flow, slower pressure decay in diastole, and reduced WSS throughout the cardiac cycle. Actual time-averaged differences between ambulatory individuals and SCI patients, although not measured, were likely to be much greater given the profound influence of lower extremity ambulation on aortic WSS. Whether SCI-specific hemodynamic conditions are the primary influence for or a consequence of accelerated aortic remodeling and aneurysmal degeneration awaits further investigation. These findings, if confirmed in larger studies, provide justification for AAA screening for SCI patients. These findings also provide additional confirmation that lower extremity exercise is a significant deterrent to aortic disease and AAA formation. The precise value of exercise in preventing aortic degeneration should be determined by a scientifically valid trial of supervised exercise testing in patients at risk for AAA disease.37Cornhill J.F. Herderick E.E. Stary H.C. Topography of human aortic sudanophilic lesions.Monogr Atheroscler. 1990; 15: 13-19PubMed Google Scholar" @default.
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• W2023444440 date "2006-12-01" @default.
• W2023444440 modified "2023-09-27" @default.
• W2023444440 title "Aortoiliac hemodynamic and morphologic adaptation to chronic spinal cord injury" @default.
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• W2023444440 doi "https://doi.org/10.1016/j.jvs.2006.08.026" @default.
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