FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023444929> ?p ?o ?g. }

• W2023444929 endingPage "e55910" @default.
• W2023444929 startingPage "e55910" @default.
• W2023444929 abstract "Triple negative breast cancer (TNBC) is a heterogeneous disease at the molecular, pathologic and clinical levels. To stratify TNBCs, we determined microRNA (miRNA) expression profiles, as well as expression profiles of a cancer-focused mRNA panel, in tumor, adjacent non-tumor (normal) and lymph node metastatic lesion (mets) tissues, from 173 women with TNBCs; we linked specific miRNA signatures to patient survival and used miRNA/mRNA anti-correlations to identify clinically and genetically different TNBC subclasses. We also assessed miRNA signatures as potential regulators of TNBC subclass-specific gene expression networks defined by expression of canonical signal pathways. Tissue specific miRNAs and mRNAs were identified for normal vs tumor vs mets comparisons. miRNA signatures correlated with prognosis were identified and predicted anti-correlated targets within the mRNA profile were defined. Two miRNA signatures (miR-16, 155, 125b, 374a and miR-16, 125b, 374a, 374b, 421, 655, 497) predictive of overall survival (P = 0.05) and distant-disease free survival (P = 0.009), respectively, were identified for patients 50 yrs of age or younger. By multivariate analysis the risk signatures were independent predictors for overall survival and distant-disease free survival. mRNA expression profiling, using the cancer-focused mRNA panel, resulted in clustering of TNBCs into 4 molecular subclasses with different expression signatures anti-correlated with the prognostic miRNAs. Our findings suggest that miRNAs play a key role in triple negative breast cancer through their ability to regulate fundamental pathways such as: cellular growth and proliferation, cellular movement and migration, Extra Cellular Matrix degradation. The results define miRNA expression signatures that characterize and contribute to the phenotypic diversity of TNBC and its metastasis." @default.
• W2023444929 created "2016-06-24" @default.
• W2023444929 creator A5000272110 @default.
• W2023444929 creator A5002936699 @default.
• W2023444929 creator A5012373469 @default.
• W2023444929 creator A5012537023 @default.
• W2023444929 creator A5016132851 @default.
• W2023444929 creator A5020751303 @default.
• W2023444929 creator A5040947074 @default.
• W2023444929 creator A5051867478 @default.
• W2023444929 creator A5057481978 @default.
• W2023444929 creator A5068356269 @default.
• W2023444929 creator A5079700663 @default.
• W2023444929 creator A5086420049 @default.
• W2023444929 date "2013-02-06" @default.
• W2023444929 modified "2023-10-01" @default.
• W2023444929 title "Integrated MicroRNA and mRNA Signatures Associated with Survival in Triple Negative Breast Cancer" @default.
• W2023444929 cites W1516095885 @default.
• W2023444929 cites W1546952499 @default.
• W2023444929 cites W1965371218 @default.
• W2023444929 cites W1967809348 @default.
• W2023444929 cites W1973281089 @default.
• W2023444929 cites W1973461983 @default.
• W2023444929 cites W1978944350 @default.
• W2023444929 cites W1980434405 @default.
• W2023444929 cites W1980768574 @default.
• W2023444929 cites W1981052185 @default.
• W2023444929 cites W1984562552 @default.
• W2023444929 cites W1988163167 @default.
• W2023444929 cites W1990316038 @default.
• W2023444929 cites W1995830102 @default.
• W2023444929 cites W2002800994 @default.
• W2023444929 cites W2006637448 @default.
• W2023444929 cites W2012247886 @default.
• W2023444929 cites W2021717492 @default.
• W2023444929 cites W2023016929 @default.
• W2023444929 cites W2023694015 @default.
• W2023444929 cites W2029243859 @default.
• W2023444929 cites W2032458681 @default.
• W2023444929 cites W2040526386 @default.
• W2023444929 cites W2042889750 @default.
• W2023444929 cites W2044880285 @default.
• W2023444929 cites W2054567240 @default.
• W2023444929 cites W2058328925 @default.
• W2023444929 cites W2091309870 @default.
• W2023444929 cites W2092868756 @default.
• W2023444929 cites W2098150383 @default.
• W2023444929 cites W2102899135 @default.
• W2023444929 cites W2122994524 @default.
• W2023444929 cites W2124007301 @default.
• W2023444929 cites W2130423812 @default.
• W2023444929 cites W2134539328 @default.
• W2023444929 cites W2135836598 @default.
• W2023444929 cites W2138749386 @default.
• W2023444929 cites W2139406867 @default.
• W2023444929 cites W2142701555 @default.
• W2023444929 cites W2152310279 @default.
• W2023444929 cites W2157285286 @default.
• W2023444929 cites W2162674813 @default.
• W2023444929 cites W2164160040 @default.
• W2023444929 cites W2168229622 @default.
• W2023444929 cites W2168747781 @default.
• W2023444929 cites W2169621060 @default.
• W2023444929 cites W4242743062 @default.
• W2023444929 doi "https://doi.org/10.1371/journal.pone.0055910" @default.
• W2023444929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3566108" @default.
• W2023444929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23405235" @default.
• W2023444929 hasPublicationYear "2013" @default.
• W2023444929 type Work @default.
• W2023444929 sameAs 2023444929 @default.
• W2023444929 citedByCount "153" @default.
• W2023444929 countsByYear W20234449292013 @default.
• W2023444929 countsByYear W20234449292014 @default.
• W2023444929 countsByYear W20234449292015 @default.
• W2023444929 countsByYear W20234449292016 @default.
• W2023444929 countsByYear W20234449292017 @default.
• W2023444929 countsByYear W20234449292018 @default.
• W2023444929 countsByYear W20234449292019 @default.
• W2023444929 countsByYear W20234449292020 @default.
• W2023444929 countsByYear W20234449292021 @default.
• W2023444929 countsByYear W20234449292022 @default.
• W2023444929 countsByYear W20234449292023 @default.
• W2023444929 crossrefType "journal-article" @default.
• W2023444929 hasAuthorship W2023444929A5000272110 @default.
• W2023444929 hasAuthorship W2023444929A5002936699 @default.
• W2023444929 hasAuthorship W2023444929A5012373469 @default.
• W2023444929 hasAuthorship W2023444929A5012537023 @default.
• W2023444929 hasAuthorship W2023444929A5016132851 @default.
• W2023444929 hasAuthorship W2023444929A5020751303 @default.
• W2023444929 hasAuthorship W2023444929A5040947074 @default.
• W2023444929 hasAuthorship W2023444929A5051867478 @default.
• W2023444929 hasAuthorship W2023444929A5057481978 @default.
• W2023444929 hasAuthorship W2023444929A5068356269 @default.
• W2023444929 hasAuthorship W2023444929A5079700663 @default.
• W2023444929 hasAuthorship W2023444929A5086420049 @default.
• W2023444929 hasBestOaLocation W20234449291 @default.
• W2023444929 hasConcept C104317684 @default.
• W2023444929 hasConcept C121608353 @default.

• next