FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023447984> ?p ?o ?g. }

• W2023447984 endingPage "17" @default.
• W2023447984 startingPage "10" @default.
• W2023447984 abstract "PURPOSE: To evaluate the efficacy and tolerability of pioglitazone in combination with a sulfonylurea in the treatment of type 2 diabetes mellitus. SUBJECTS AND METHODS: This 16-week, double-blind study included patients on a stable regimen of a sulfonylurea for ≥30 days and with a glycosylated hemoglobin (HbA1C) level ≥8.0%. Patients were randomly assigned to receive once daily pioglitazone 15 mg (n = 184), pioglitazone 30 mg (n = 189), or placebo plus sulfonylurea (n = 187). RESULTS: Patients receiving pioglitazone + sulfonylurea had significant (P <0.05) decreases from baseline in HbA1C and fasting plasma glucose levels compared with patients treated with placebo + sulfonylurea. As compared with placebo, HbA1C decreased by 0.9% (95% confidence interval [CI]: 0.06% to 1.2%) with pioglitazone 15 mg and 1.3% (CI: 1% to 1.6%) with 30 mg pioglitazone; fasting plasma glucose levels decreased by 39 mg/dL (95% CI: 27 to 52 mg/dL) with pioglitazone 15 mg and by 58 mg/dL (95% CI: 46–70 mg/dL) with 30 mg pioglitazone. Both pioglitazone + sulfonylurea groups had significant (P <0.05) mean percent decreases in triglyceride levels (17%, 95% CI: 6% to 27% for 15 mg; 26%, 95% CI: 16% to 36% for 30 mg) and increases in high-density lipoprotein cholesterol levels (6%, 95% CI: 1% to 11% for 15 mg; 13%, CI: 8% to 18% for 30 mg) compared with placebo + sulfonylurea. There were small but statistically significant mean percent increases in low-density lipoprotein cholesterol levels in all groups. Pioglitazone was well tolerated, and the rates of adverse events were similar in all groups. CONCLUSION: In patients with type 2 diabetes, pioglitazone plus sulfonylurea significantly improves HbA1C and fasting plasma glucose levels with beneficial effects on serum triglyceride and HDL-cholesterol levels." @default.
• W2023447984 created "2016-06-24" @default.
• W2023447984 creator A5008749974 @default.
• W2023447984 creator A5048111076 @default.
• W2023447984 creator A5054183066 @default.
• W2023447984 creator A5067658931 @default.
• W2023447984 creator A5079527249 @default.
• W2023447984 creator A5082480308 @default.
• W2023447984 date "2001-07-01" @default.
• W2023447984 modified "2023-10-17" @default.
• W2023447984 title "Pioglitazone hydrochloride in combination with sulfonylurea therapy improves glycemic control in patients with type 2 diabetes mellitus: a randomized, placebo-controlled study" @default.
• W2023447984 cites W1860005265 @default.
• W2023447984 cites W1971817110 @default.
• W2023447984 cites W1977548021 @default.
• W2023447984 cites W1984081543 @default.
• W2023447984 cites W2005258216 @default.
• W2023447984 cites W2013408977 @default.
• W2023447984 cites W2015279471 @default.
• W2023447984 cites W2031831221 @default.
• W2023447984 cites W2036939737 @default.
• W2023447984 cites W2043269645 @default.
• W2023447984 cites W2047853908 @default.
• W2023447984 cites W2078089300 @default.
• W2023447984 cites W2088065710 @default.
• W2023447984 cites W2111587709 @default.
• W2023447984 cites W2116404316 @default.
• W2023447984 cites W2337454357 @default.
• W2023447984 cites W3190844582 @default.
• W2023447984 cites W4236613961 @default.
• W2023447984 cites W4248066341 @default.
• W2023447984 doi "https://doi.org/10.1016/s0002-9343(01)00713-6" @default.
• W2023447984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11448655" @default.
• W2023447984 hasPublicationYear "2001" @default.
• W2023447984 type Work @default.
• W2023447984 sameAs 2023447984 @default.
• W2023447984 citedByCount "257" @default.
• W2023447984 countsByYear W20234479842012 @default.
• W2023447984 countsByYear W20234479842013 @default.
• W2023447984 countsByYear W20234479842014 @default.
• W2023447984 countsByYear W20234479842015 @default.
• W2023447984 countsByYear W20234479842016 @default.
• W2023447984 countsByYear W20234479842018 @default.
• W2023447984 countsByYear W20234479842019 @default.
• W2023447984 countsByYear W20234479842020 @default.
• W2023447984 countsByYear W20234479842021 @default.
• W2023447984 crossrefType "journal-article" @default.
• W2023447984 hasAuthorship W2023447984A5008749974 @default.
• W2023447984 hasAuthorship W2023447984A5048111076 @default.
• W2023447984 hasAuthorship W2023447984A5054183066 @default.
• W2023447984 hasAuthorship W2023447984A5067658931 @default.
• W2023447984 hasAuthorship W2023447984A5079527249 @default.
• W2023447984 hasAuthorship W2023447984A5082480308 @default.
• W2023447984 hasConcept C126322002 @default.
• W2023447984 hasConcept C134018914 @default.
• W2023447984 hasConcept C142724271 @default.
• W2023447984 hasConcept C197934379 @default.
• W2023447984 hasConcept C204787440 @default.
• W2023447984 hasConcept C27081682 @default.
• W2023447984 hasConcept C2777180221 @default.
• W2023447984 hasConcept C2777538456 @default.
• W2023447984 hasConcept C2778163477 @default.
• W2023447984 hasConcept C2778375690 @default.
• W2023447984 hasConcept C2778384471 @default.
• W2023447984 hasConcept C2778854520 @default.
• W2023447984 hasConcept C2778913445 @default.
• W2023447984 hasConcept C2780473172 @default.
• W2023447984 hasConcept C2910068830 @default.
• W2023447984 hasConcept C555293320 @default.
• W2023447984 hasConcept C71924100 @default.
• W2023447984 hasConcept C90924648 @default.
• W2023447984 hasConceptScore W2023447984C126322002 @default.
• W2023447984 hasConceptScore W2023447984C134018914 @default.
• W2023447984 hasConceptScore W2023447984C142724271 @default.
• W2023447984 hasConceptScore W2023447984C197934379 @default.
• W2023447984 hasConceptScore W2023447984C204787440 @default.
• W2023447984 hasConceptScore W2023447984C27081682 @default.
• W2023447984 hasConceptScore W2023447984C2777180221 @default.
• W2023447984 hasConceptScore W2023447984C2777538456 @default.
• W2023447984 hasConceptScore W2023447984C2778163477 @default.
• W2023447984 hasConceptScore W2023447984C2778375690 @default.
• W2023447984 hasConceptScore W2023447984C2778384471 @default.
• W2023447984 hasConceptScore W2023447984C2778854520 @default.
• W2023447984 hasConceptScore W2023447984C2778913445 @default.
• W2023447984 hasConceptScore W2023447984C2780473172 @default.
• W2023447984 hasConceptScore W2023447984C2910068830 @default.
• W2023447984 hasConceptScore W2023447984C555293320 @default.
• W2023447984 hasConceptScore W2023447984C71924100 @default.
• W2023447984 hasConceptScore W2023447984C90924648 @default.
• W2023447984 hasIssue "1" @default.
• W2023447984 hasLocation W20234479841 @default.
• W2023447984 hasLocation W20234479842 @default.
• W2023447984 hasOpenAccess W2023447984 @default.
• W2023447984 hasPrimaryLocation W20234479841 @default.
• W2023447984 hasRelatedWork W2020932776 @default.
• W2023447984 hasRelatedWork W2081200653 @default.
• W2023447984 hasRelatedWork W2118518734 @default.
• W2023447984 hasRelatedWork W2492679743 @default.
• W2023447984 hasRelatedWork W2752583015 @default.

• next