FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023448051> ?p ?o ?g. }

• W2023448051 endingPage "1218" @default.
• W2023448051 startingPage "1202" @default.
• W2023448051 abstract "Fungal metabolites with an epi-oligothiadiketopiperazine structure, TAN-1496 A, C and E, were isolated from the culture broth of Microsphaeropsis sp. FL-16144. Their molecular formulas were determined to be C22H28N2O9S2, C22H28N2O9S3 and C22H28N2O9S4, respectively. Structures were determined by comparing the NMR data with those of known diketopiperazine antibiotics, sirodesmins. These metabolites inhibited the relaxation of supercoiled pBR322 DNA by calf thymus topoisomerase I but did not affect the decatenation of kinetoplast DNA by calf thymus topoisomerase II at concentration up to 500 microM. They strongly suppressed the growth of various murine and human tumor cells and induced apoptosis. Moreover, various derivatives were synthesized to investigate the relationship of their functional groups and biological activities." @default.
• W2023448051 created "2016-06-24" @default.
• W2023448051 creator A5001609593 @default.
• W2023448051 creator A5012067791 @default.
• W2023448051 creator A5023209235 @default.
• W2023448051 creator A5044139141 @default.
• W2023448051 creator A5049071641 @default.
• W2023448051 date "1994-01-01" @default.
• W2023448051 modified "2023-10-16" @default.
• W2023448051 title "TAN-1496 A, C and E, diketopiperazine antibiotics with inhibitory activity against mammalian DNA topoisomerase I." @default.
• W2023448051 cites W1476133568 @default.
• W2023448051 cites W1568951994 @default.
• W2023448051 cites W1589289634 @default.
• W2023448051 cites W1814627583 @default.
• W2023448051 cites W1971928740 @default.
• W2023448051 cites W1985465535 @default.
• W2023448051 cites W1993094619 @default.
• W2023448051 cites W2015978861 @default.
• W2023448051 cites W2037328302 @default.
• W2023448051 cites W2057409012 @default.
• W2023448051 cites W2059466357 @default.
• W2023448051 cites W2068431848 @default.
• W2023448051 cites W2101647884 @default.
• W2023448051 cites W2118094114 @default.
• W2023448051 cites W2148045717 @default.
• W2023448051 cites W2313001972 @default.
• W2023448051 cites W2314448238 @default.
• W2023448051 cites W2394674068 @default.
• W2023448051 cites W2413119228 @default.
• W2023448051 cites W2488389492 @default.
• W2023448051 cites W30282213 @default.
• W2023448051 doi "https://doi.org/10.7164/antibiotics.47.1202" @default.
• W2023448051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8002382" @default.
• W2023448051 hasPublicationYear "1994" @default.
• W2023448051 type Work @default.
• W2023448051 sameAs 2023448051 @default.
• W2023448051 citedByCount "53" @default.
• W2023448051 countsByYear W20234480512012 @default.
• W2023448051 countsByYear W20234480512014 @default.
• W2023448051 countsByYear W20234480512017 @default.
• W2023448051 countsByYear W20234480512021 @default.
• W2023448051 crossrefType "journal-article" @default.
• W2023448051 hasAuthorship W2023448051A5001609593 @default.
• W2023448051 hasAuthorship W2023448051A5012067791 @default.
• W2023448051 hasAuthorship W2023448051A5023209235 @default.
• W2023448051 hasAuthorship W2023448051A5044139141 @default.
• W2023448051 hasAuthorship W2023448051A5049071641 @default.
• W2023448051 hasBestOaLocation W20234480511 @default.
• W2023448051 hasConcept C104317684 @default.
• W2023448051 hasConcept C116073593 @default.
• W2023448051 hasConcept C147897179 @default.
• W2023448051 hasConcept C153911025 @default.
• W2023448051 hasConcept C158456008 @default.
• W2023448051 hasConcept C167125095 @default.
• W2023448051 hasConcept C185592680 @default.
• W2023448051 hasConcept C190283241 @default.
• W2023448051 hasConcept C202751555 @default.
• W2023448051 hasConcept C2776027055 @default.
• W2023448051 hasConcept C501593827 @default.
• W2023448051 hasConcept C547475151 @default.
• W2023448051 hasConcept C552990157 @default.
• W2023448051 hasConcept C55493867 @default.
• W2023448051 hasConcept C64241487 @default.
• W2023448051 hasConcept C71240020 @default.
• W2023448051 hasConcept C73573662 @default.
• W2023448051 hasConcept C86803240 @default.
• W2023448051 hasConceptScore W2023448051C104317684 @default.
• W2023448051 hasConceptScore W2023448051C116073593 @default.
• W2023448051 hasConceptScore W2023448051C147897179 @default.
• W2023448051 hasConceptScore W2023448051C153911025 @default.
• W2023448051 hasConceptScore W2023448051C158456008 @default.
• W2023448051 hasConceptScore W2023448051C167125095 @default.
• W2023448051 hasConceptScore W2023448051C185592680 @default.
• W2023448051 hasConceptScore W2023448051C190283241 @default.
• W2023448051 hasConceptScore W2023448051C202751555 @default.
• W2023448051 hasConceptScore W2023448051C2776027055 @default.
• W2023448051 hasConceptScore W2023448051C501593827 @default.
• W2023448051 hasConceptScore W2023448051C547475151 @default.
• W2023448051 hasConceptScore W2023448051C552990157 @default.
• W2023448051 hasConceptScore W2023448051C55493867 @default.
• W2023448051 hasConceptScore W2023448051C64241487 @default.
• W2023448051 hasConceptScore W2023448051C71240020 @default.
• W2023448051 hasConceptScore W2023448051C73573662 @default.
• W2023448051 hasConceptScore W2023448051C86803240 @default.
• W2023448051 hasIssue "11" @default.
• W2023448051 hasLocation W20234480511 @default.
• W2023448051 hasLocation W20234480512 @default.
• W2023448051 hasOpenAccess W2023448051 @default.
• W2023448051 hasPrimaryLocation W20234480511 @default.
• W2023448051 hasRelatedWork W1964037253 @default.
• W2023448051 hasRelatedWork W2035990717 @default.
• W2023448051 hasRelatedWork W2074194645 @default.
• W2023448051 hasRelatedWork W2142727309 @default.
• W2023448051 hasRelatedWork W2286143518 @default.
• W2023448051 hasRelatedWork W2316674713 @default.
• W2023448051 hasRelatedWork W4210393371 @default.
• W2023448051 hasRelatedWork W4246645760 @default.
• W2023448051 hasRelatedWork W4251406891 @default.

• next