FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023449363> ?p ?o ?g. }

• W2023449363 endingPage "1550" @default.
• W2023449363 startingPage "1546" @default.
• W2023449363 abstract "Children with gastroesophageal reflux often suffer from chronic, severe lung damage and recurrent infections. The mechanisms may involve reflux induced lung injury with alterations of the surfactant proteins (SP) SP-A and SP-D, which bind specifically to various microbes and increase their elimination by granular leukocytes and macrophages. In 20 children with gastroesophageal reflux disease (GERD) the bronchoalveolar lavage content and macromolecular organization of SP-A and SP-D was determined by enzyme linked immunosorbent assay and gel chromatography. For comparison, lavages from 17 children without respiratory diseases were investigated. Both, SP-A and SP-D were significantly reduced in children with GERD-median (25, 75 percentiles) SP-A: 362 (169, 494) ng/ml versus 867 (656, 1,761) in control subjects and SP-D: 174 (73, 456) ng/ml versus 518 (295, 748) ng/ml in control subjects. The more active, higher molecular weight oligomers of SP-A and especially those of SP-D were diminished, whereas the smaller sized forms of SP-D were markedly increased. In children with GERD, significantly reduced amounts of SP-A and SP-D and an altered structural organization of the surfactant protein oligomers were demonstrated. Such impairments of central components of the innate host defense system may contribute to the pathogenesis of the chronic lung disease commonly observed in these children." @default.
• W2023449363 created "2016-06-24" @default.
• W2023449363 creator A5048818819 @default.
• W2023449363 creator A5060791669 @default.
• W2023449363 creator A5065547785 @default.
• W2023449363 creator A5088743958 @default.
• W2023449363 date "2002-06-01" @default.
• W2023449363 modified "2023-09-27" @default.
• W2023449363 title "Surfactant Proteins A and D in Children with Pulmonary Disease due to Gastroesophageal Reflux" @default.
• W2023449363 cites W1270417454 @default.
• W2023449363 cites W131308053 @default.
• W2023449363 cites W1965746614 @default.
• W2023449363 cites W2001597538 @default.
• W2023449363 cites W2013683926 @default.
• W2023449363 cites W2018404794 @default.
• W2023449363 cites W2020012047 @default.
• W2023449363 cites W2044279773 @default.
• W2023449363 cites W2067698342 @default.
• W2023449363 cites W2070364452 @default.
• W2023449363 cites W2072419995 @default.
• W2023449363 cites W2083494967 @default.
• W2023449363 cites W2085809824 @default.
• W2023449363 cites W2089143719 @default.
• W2023449363 cites W2105254430 @default.
• W2023449363 cites W2116046790 @default.
• W2023449363 cites W2121403538 @default.
• W2023449363 cites W2124366530 @default.
• W2023449363 cites W2143909959 @default.
• W2023449363 cites W2165893661 @default.
• W2023449363 cites W4236842068 @default.
• W2023449363 doi "https://doi.org/10.1164/rccm.2107147" @default.
• W2023449363 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12045131" @default.
• W2023449363 hasPublicationYear "2002" @default.
• W2023449363 type Work @default.
• W2023449363 sameAs 2023449363 @default.
• W2023449363 citedByCount "52" @default.
• W2023449363 countsByYear W20234493632012 @default.
• W2023449363 countsByYear W20234493632013 @default.
• W2023449363 countsByYear W20234493632014 @default.
• W2023449363 countsByYear W20234493632016 @default.
• W2023449363 countsByYear W20234493632018 @default.
• W2023449363 countsByYear W20234493632019 @default.
• W2023449363 countsByYear W20234493632021 @default.
• W2023449363 crossrefType "journal-article" @default.
• W2023449363 hasAuthorship W2023449363A5048818819 @default.
• W2023449363 hasAuthorship W2023449363A5060791669 @default.
• W2023449363 hasAuthorship W2023449363A5065547785 @default.
• W2023449363 hasAuthorship W2023449363A5088743958 @default.
• W2023449363 hasConcept C126322002 @default.
• W2023449363 hasConcept C136449434 @default.
• W2023449363 hasConcept C142724271 @default.
• W2023449363 hasConcept C170493617 @default.
• W2023449363 hasConcept C203014093 @default.
• W2023449363 hasConcept C2776178081 @default.
• W2023449363 hasConcept C2777014526 @default.
• W2023449363 hasConcept C2777438239 @default.
• W2023449363 hasConcept C2777714996 @default.
• W2023449363 hasConcept C2777961210 @default.
• W2023449363 hasConcept C2779134260 @default.
• W2023449363 hasConcept C2780942790 @default.
• W2023449363 hasConcept C43270747 @default.
• W2023449363 hasConcept C55493867 @default.
• W2023449363 hasConcept C58226133 @default.
• W2023449363 hasConcept C71924100 @default.
• W2023449363 hasConcept C86803240 @default.
• W2023449363 hasConcept C90924648 @default.
• W2023449363 hasConceptScore W2023449363C126322002 @default.
• W2023449363 hasConceptScore W2023449363C136449434 @default.
• W2023449363 hasConceptScore W2023449363C142724271 @default.
• W2023449363 hasConceptScore W2023449363C170493617 @default.
• W2023449363 hasConceptScore W2023449363C203014093 @default.
• W2023449363 hasConceptScore W2023449363C2776178081 @default.
• W2023449363 hasConceptScore W2023449363C2777014526 @default.
• W2023449363 hasConceptScore W2023449363C2777438239 @default.
• W2023449363 hasConceptScore W2023449363C2777714996 @default.
• W2023449363 hasConceptScore W2023449363C2777961210 @default.
• W2023449363 hasConceptScore W2023449363C2779134260 @default.
• W2023449363 hasConceptScore W2023449363C2780942790 @default.
• W2023449363 hasConceptScore W2023449363C43270747 @default.
• W2023449363 hasConceptScore W2023449363C55493867 @default.
• W2023449363 hasConceptScore W2023449363C58226133 @default.
• W2023449363 hasConceptScore W2023449363C71924100 @default.
• W2023449363 hasConceptScore W2023449363C86803240 @default.
• W2023449363 hasConceptScore W2023449363C90924648 @default.
• W2023449363 hasIssue "11" @default.
• W2023449363 hasLocation W20234493631 @default.
• W2023449363 hasLocation W20234493632 @default.
• W2023449363 hasOpenAccess W2023449363 @default.
• W2023449363 hasPrimaryLocation W20234493631 @default.
• W2023449363 hasRelatedWork W1971632193 @default.
• W2023449363 hasRelatedWork W2015661160 @default.
• W2023449363 hasRelatedWork W2022311620 @default.
• W2023449363 hasRelatedWork W2023449363 @default.
• W2023449363 hasRelatedWork W2356299640 @default.
• W2023449363 hasRelatedWork W2381168924 @default.
• W2023449363 hasRelatedWork W2772654920 @default.
• W2023449363 hasRelatedWork W2783568912 @default.
• W2023449363 hasRelatedWork W2992861500 @default.

• next