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- W2023450134 endingPage "100" @default.
- W2023450134 startingPage "89" @default.
- W2023450134 abstract "Herpesviruses have evolved several effective strategies to counter the host immune response. Chief among these is inhibition of the host MHC class I antigen processing and presentation pathway, thereby reducing the presentation of virus-derived epitopes on the surface of the infected cell. This review summarizes the mechanisms used by herpesviruses to achieve this goal, including shut-down of MHC class I molecule synthesis, blockage of proteasome-mediated peptide generation and prevention of TAP-mediated peptide transport. Furthermore, herpesvirus proteins can retain MHC class I molecules in the endoplasmic reticulum, or direct their retrograde translocation from the endoplasmic reticulum or endocytosis from the plasma membrane, with subsequent degradation. The resulting down-regulation of cell surface MHC class I peptide complexes thwarts the ability of cytotoxic T lymphocytes to recognize and eliminate virus-infected cells. The subversion of the natural killer cell response by herpesvirus proteins and microRNAs is also discussed." @default.
- W2023450134 created "2016-06-24" @default.
- W2023450134 creator A5030181676 @default.
- W2023450134 creator A5042316785 @default.
- W2023450134 creator A5045879185 @default.
- W2023450134 date "2010-06-01" @default.
- W2023450134 modified "2023-10-17" @default.
- W2023450134 title "Herpesviruses and immunity: The art of evasion" @default.
- W2023450134 cites W1525435128 @default.
- W2023450134 cites W1551238239 @default.
- W2023450134 cites W1637450726 @default.
- W2023450134 cites W1824684517 @default.
- W2023450134 cites W1900551065 @default.
- W2023450134 cites W1965827479 @default.
- W2023450134 cites W1965969172 @default.
- W2023450134 cites W1966948366 @default.
- W2023450134 cites W1970100427 @default.
- W2023450134 cites W1973085325 @default.
- W2023450134 cites W1975578460 @default.
- W2023450134 cites W1976601347 @default.
- W2023450134 cites W1978706791 @default.
- W2023450134 cites W1979011182 @default.
- W2023450134 cites W1979834833 @default.
- W2023450134 cites W1981295860 @default.
- W2023450134 cites W1981459273 @default.
- W2023450134 cites W1981625315 @default.
- W2023450134 cites W1983447693 @default.
- W2023450134 cites W1986057386 @default.
- W2023450134 cites W1986269363 @default.
- W2023450134 cites W1987135006 @default.
- W2023450134 cites W1989525395 @default.
- W2023450134 cites W1993180746 @default.
- W2023450134 cites W1995744610 @default.
- W2023450134 cites W1998643471 @default.
- W2023450134 cites W2009745195 @default.
- W2023450134 cites W2010474050 @default.
- W2023450134 cites W2010862596 @default.
- W2023450134 cites W2011017810 @default.
- W2023450134 cites W2012237359 @default.
- W2023450134 cites W2017954030 @default.
- W2023450134 cites W2018106813 @default.
- W2023450134 cites W2018841084 @default.
- W2023450134 cites W2020750867 @default.
- W2023450134 cites W2021668965 @default.
- W2023450134 cites W2021743722 @default.
- W2023450134 cites W2023168923 @default.
- W2023450134 cites W2026520054 @default.
- W2023450134 cites W2029836083 @default.
- W2023450134 cites W2030723839 @default.
- W2023450134 cites W2032612463 @default.
- W2023450134 cites W2032818498 @default.
- W2023450134 cites W2033054937 @default.
- W2023450134 cites W2033088972 @default.
- W2023450134 cites W2033313049 @default.
- W2023450134 cites W2036671510 @default.
- W2023450134 cites W2036925007 @default.
- W2023450134 cites W2037394274 @default.
- W2023450134 cites W2037788616 @default.
- W2023450134 cites W2045407060 @default.
- W2023450134 cites W2048737737 @default.
- W2023450134 cites W2049773295 @default.
- W2023450134 cites W2049882078 @default.
- W2023450134 cites W2056305383 @default.
- W2023450134 cites W2057571516 @default.
- W2023450134 cites W2058168682 @default.
- W2023450134 cites W2058209707 @default.
- W2023450134 cites W2058676387 @default.
- W2023450134 cites W2060336613 @default.
- W2023450134 cites W2062999927 @default.
- W2023450134 cites W2063317473 @default.
- W2023450134 cites W2064609154 @default.
- W2023450134 cites W2065770450 @default.
- W2023450134 cites W2069624186 @default.
- W2023450134 cites W2071652768 @default.
- W2023450134 cites W2072602437 @default.
- W2023450134 cites W2073330288 @default.
- W2023450134 cites W2074876842 @default.
- W2023450134 cites W2077291760 @default.
- W2023450134 cites W2080426618 @default.
- W2023450134 cites W2080566427 @default.
- W2023450134 cites W2081104776 @default.
- W2023450134 cites W2081376834 @default.
- W2023450134 cites W2082786982 @default.
- W2023450134 cites W2083892257 @default.
- W2023450134 cites W2085610443 @default.
- W2023450134 cites W2087462807 @default.
- W2023450134 cites W2088254329 @default.
- W2023450134 cites W2092411293 @default.
- W2023450134 cites W2095046069 @default.
- W2023450134 cites W2096894782 @default.
- W2023450134 cites W2098159895 @default.
- W2023450134 cites W2098702227 @default.
- W2023450134 cites W2100085836 @default.
- W2023450134 cites W2101328506 @default.
- W2023450134 cites W2103548051 @default.
- W2023450134 cites W2103824932 @default.
- W2023450134 cites W2113029463 @default.
- W2023450134 cites W2113164415 @default.