FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023453192> ?p ?o ?g. }

• W2023453192 endingPage "38" @default.
• W2023453192 startingPage "29" @default.
• W2023453192 abstract "Homer is a family of cytoplasmic adaptor proteins that play different roles in cell function, including the regulation of G-protein-coupled receptors. These proteins contain an Ena (Enabled)/VASP (vasodilator-stimulated phosphoprotein) homology 1 domain that binds to the PPXXF sequence motif, which is present in different Ca²⁺-handling proteins such as IP3 (inositol 1,4,5-trisphosphate) receptors and TRPC (transient receptor potential canonical) channels. In the present study we show evidence for a role of Homer proteins in the STIM1 (stromal interaction molecule 1)-Orai1 association, as well as in the TRPC1-IP3RII (type II IP3 receptor) interaction, which might be of relevance in platelet function. Treatment of human platelets with thapsigargin or thrombin results in a Ca²⁺-independent association of Homer1 with TRPC1 and IP3RII. In addition, thapsigargin and thrombin enhanced the association of Homer1 with STIM1 and Orai1 in a Ca²⁺-dependent manner. Interference with Homer function by introduction of the synthetic PPKKFR peptide into cells, which emulates the proline-rich sequences of the PPXXF motif, reduced STIM1-Orai1 and TRPC1- IP3RII associations, as compared with the introduction of the inactive PPKKRR peptide. The PPKKFR peptide attenuates thrombin-evoked Ca²⁺ entry and the maintenance of thapsigargin-induced store-operated Ca²⁺ entry. Finally, the PPKKFR peptide attenuated thrombin-induced platelet aggregation. The findings of the present study support an important role for Homer proteins in thrombin-stimulated platelet function, which is likely to be mediated by the support of agonist-induced Ca²⁺ entry." @default.
• W2023453192 created "2016-06-24" @default.
• W2023453192 creator A5011107308 @default.
• W2023453192 creator A5036708850 @default.
• W2023453192 creator A5079551707 @default.
• W2023453192 creator A5080498077 @default.
• W2023453192 creator A5091536895 @default.
• W2023453192 date "2012-06-15" @default.
• W2023453192 modified "2023-09-23" @default.
• W2023453192 title "Homers regulate calcium entry and aggregation in human platelets: a role for Homers in the association between STIM1 and Orai1" @default.
• W2023453192 cites W1840777802 @default.
• W2023453192 cites W1856053518 @default.
• W2023453192 cites W1964287631 @default.
• W2023453192 cites W1966761076 @default.
• W2023453192 cites W1970641636 @default.
• W2023453192 cites W1973819000 @default.
• W2023453192 cites W1976566307 @default.
• W2023453192 cites W1978079833 @default.
• W2023453192 cites W1981050975 @default.
• W2023453192 cites W1984282445 @default.
• W2023453192 cites W2011135007 @default.
• W2023453192 cites W2015166032 @default.
• W2023453192 cites W2022719025 @default.
• W2023453192 cites W2027094257 @default.
• W2023453192 cites W2028175193 @default.
• W2023453192 cites W2028649950 @default.
• W2023453192 cites W2028913177 @default.
• W2023453192 cites W2039473620 @default.
• W2023453192 cites W2042888704 @default.
• W2023453192 cites W2046694790 @default.
• W2023453192 cites W2054081721 @default.
• W2023453192 cites W2058605814 @default.
• W2023453192 cites W2064583017 @default.
• W2023453192 cites W2067449516 @default.
• W2023453192 cites W2071405646 @default.
• W2023453192 cites W2072515967 @default.
• W2023453192 cites W2074966060 @default.
• W2023453192 cites W2080861637 @default.
• W2023453192 cites W2091626869 @default.
• W2023453192 cites W2101586949 @default.
• W2023453192 cites W2101873410 @default.
• W2023453192 cites W2108222684 @default.
• W2023453192 cites W2111132110 @default.
• W2023453192 cites W2124561894 @default.
• W2023453192 cites W2124641117 @default.
• W2023453192 cites W2141260882 @default.
• W2023453192 cites W2145789165 @default.
• W2023453192 cites W2163789582 @default.
• W2023453192 cites W2164762131 @default.
• W2023453192 doi "https://doi.org/10.1042/bj20120471" @default.
• W2023453192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22506990" @default.
• W2023453192 hasPublicationYear "2012" @default.
• W2023453192 type Work @default.
• W2023453192 sameAs 2023453192 @default.
• W2023453192 citedByCount "34" @default.
• W2023453192 countsByYear W20234531922012 @default.
• W2023453192 countsByYear W20234531922013 @default.
• W2023453192 countsByYear W20234531922014 @default.
• W2023453192 countsByYear W20234531922015 @default.
• W2023453192 countsByYear W20234531922016 @default.
• W2023453192 countsByYear W20234531922017 @default.
• W2023453192 countsByYear W20234531922018 @default.
• W2023453192 countsByYear W20234531922019 @default.
• W2023453192 countsByYear W20234531922020 @default.
• W2023453192 countsByYear W20234531922021 @default.
• W2023453192 countsByYear W20234531922022 @default.
• W2023453192 countsByYear W20234531922023 @default.
• W2023453192 crossrefType "journal-article" @default.
• W2023453192 hasAuthorship W2023453192A5011107308 @default.
• W2023453192 hasAuthorship W2023453192A5036708850 @default.
• W2023453192 hasAuthorship W2023453192A5079551707 @default.
• W2023453192 hasAuthorship W2023453192A5080498077 @default.
• W2023453192 hasAuthorship W2023453192A5091536895 @default.
• W2023453192 hasConcept C155164980 @default.
• W2023453192 hasConcept C158617107 @default.
• W2023453192 hasConcept C162740809 @default.
• W2023453192 hasConcept C167007842 @default.
• W2023453192 hasConcept C170488646 @default.
• W2023453192 hasConcept C170493617 @default.
• W2023453192 hasConcept C185592680 @default.
• W2023453192 hasConcept C203014093 @default.
• W2023453192 hasConcept C2776610495 @default.
• W2023453192 hasConcept C2777146706 @default.
• W2023453192 hasConcept C2777292125 @default.
• W2023453192 hasConcept C2780383360 @default.
• W2023453192 hasConcept C55493867 @default.
• W2023453192 hasConcept C86803240 @default.
• W2023453192 hasConcept C89560881 @default.
• W2023453192 hasConcept C95444343 @default.
• W2023453192 hasConceptScore W2023453192C155164980 @default.
• W2023453192 hasConceptScore W2023453192C158617107 @default.
• W2023453192 hasConceptScore W2023453192C162740809 @default.
• W2023453192 hasConceptScore W2023453192C167007842 @default.
• W2023453192 hasConceptScore W2023453192C170488646 @default.
• W2023453192 hasConceptScore W2023453192C170493617 @default.
• W2023453192 hasConceptScore W2023453192C185592680 @default.
• W2023453192 hasConceptScore W2023453192C203014093 @default.
• W2023453192 hasConceptScore W2023453192C2776610495 @default.

• next