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- W2023453711 endingPage "157" @default.
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- W2023453711 abstract "Drug-induced inhibition of mitochondrial fatty acid β-oxidation (mtFAO) is a key mechanism whereby drugs can induce steatosis. The type and severity of this liver lesion is dependent on the residual mtFAO flux. Indeed, a severe inhibition of mtFAO leads to microvesicular steatosis, hypoglycemia and liver failure, which can be favored by genetic predispositions. In contrast, moderate impairment of mtFAO can cause macrovacuolar steatosis, which is by itself a benign lesion. In the long-term, however, macrovacuolar steatosis can progress with some drugs to steatohepatitis. Interestingly, drugs that are more likely to cause steatohepatitis are those impairing the mitochondrial respiratory chain (MRC) activity. Indeed, MRC impairment favors not only hepatic fat accretion but also oxidative stress and lipid peroxidation. Drugs inhibiting mtFAO could be more toxic in obese patients with preexisting nonalcoholic fatty liver disease (NAFLD) since higher mtFAO is a key metabolic adaptation to curb fat accretion during NAFLD." @default.
- W2023453711 created "2016-06-24" @default.
- W2023453711 creator A5014451095 @default.
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- W2023453711 creator A5021292416 @default.
- W2023453711 creator A5021881009 @default.
- W2023453711 creator A5063215068 @default.
- W2023453711 creator A5089942508 @default.
- W2023453711 date "2013-06-28" @default.
- W2023453711 modified "2023-09-30" @default.
- W2023453711 title "Drug-Induced Inhibition of Mitochondrial Fatty Acid Oxidation and Steatosis" @default.
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