FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023454919> ?p ?o ?g. }

• W2023454919 endingPage "2785" @default.
• W2023454919 startingPage "2771" @default.
• W2023454919 abstract "Mutations in the Neurofibromatosis 2 (NF2) gene are associated with predisposition to vestibular schwannomas, spinal schwannomas, meningiomas, and ependymomas. Presently, how NF2 is expressed during embryonic development and in the tissues affected by neurofibromatosis type 2 (NF2) has not been well defined. To examine NF2 expression in vivo, we generated transgenic mice carrying a 2.4-kb NF2 promoter driving beta-galactosidase (beta-gal) with a nuclear localization signal. Whole-mount embryo staining revealed that the NF2 promoter directed beta-gal expression as early as embryonic day E5.5. Strong expression was detected at E6.5 in the embryonic ectoderm containing many mitotic cells. beta-gal staining was also found in parts of embryonic endoderm and mesoderm. The beta-gal staining pattern in the embryonic tissues was corroborated by in situ hybridization analysis of endogenous Nf2 RNA expression. Importantly, we observed strong NF2 promoter activity in the developing brain and in sites containing migrating cells including the neural tube closure, branchial arches, dorsal aorta, and paraaortic splanchnopleura. Furthermore, we noted a transient change of NF2 promoter activity during neural crest cell migration. While little beta-gal activity was detected in premigratory neural crest cells at the dorsal ridge region of the neural fold, significant activity was seen in the neural crest cells already migrating away from the dorsal neural tube. In addition, we detected considerable NF2 promoter activity in various NF2-affected tissues such as acoustic ganglion, trigeminal ganglion, spinal ganglia, optic chiasma, the ependymal cell-containing tela choroidea, and the pigmented epithelium of the retina. The NF2 promoter expression pattern during embryogenesis suggests a specific regulation of the NF2 gene during neural crest cell migration and further supports the role of merlin in cell adhesion, motility, and proliferation during development." @default.
• W2023454919 created "2016-06-24" @default.
• W2023454919 creator A5026837154 @default.
• W2023454919 creator A5056525986 @default.
• W2023454919 creator A5072720460 @default.
• W2023454919 creator A5073993996 @default.
• W2023454919 creator A5074887496 @default.
• W2023454919 creator A5087100546 @default.
• W2023454919 date "2006-09-12" @default.
• W2023454919 modified "2023-10-18" @default.
• W2023454919 title "Regulation of the Neurofibromatosis 2 gene promoter expression during embryonic development" @default.
• W2023454919 cites W1495670687 @default.
• W2023454919 cites W1565566882 @default.
• W2023454919 cites W1590118434 @default.
• W2023454919 cites W1966530523 @default.
• W2023454919 cites W1967020063 @default.
• W2023454919 cites W1968848196 @default.
• W2023454919 cites W1972452947 @default.
• W2023454919 cites W1976343564 @default.
• W2023454919 cites W1977831337 @default.
• W2023454919 cites W1985649855 @default.
• W2023454919 cites W1986128577 @default.
• W2023454919 cites W1995965267 @default.
• W2023454919 cites W2000638576 @default.
• W2023454919 cites W2012819315 @default.
• W2023454919 cites W2012873915 @default.
• W2023454919 cites W2024075568 @default.
• W2023454919 cites W2026158123 @default.
• W2023454919 cites W2026304709 @default.
• W2023454919 cites W2029976610 @default.
• W2023454919 cites W2035781246 @default.
• W2023454919 cites W2036217444 @default.
• W2023454919 cites W2036237432 @default.
• W2023454919 cites W2037159639 @default.
• W2023454919 cites W2041421563 @default.
• W2023454919 cites W2044330060 @default.
• W2023454919 cites W2050234810 @default.
• W2023454919 cites W2053547776 @default.
• W2023454919 cites W2057967850 @default.
• W2023454919 cites W2068344889 @default.
• W2023454919 cites W2090369455 @default.
• W2023454919 cites W2092186716 @default.
• W2023454919 cites W2092322285 @default.
• W2023454919 cites W2097930500 @default.
• W2023454919 cites W2121097440 @default.
• W2023454919 cites W2125613496 @default.
• W2023454919 cites W2125701677 @default.
• W2023454919 cites W2128021675 @default.
• W2023454919 cites W2133862424 @default.
• W2023454919 cites W2135432931 @default.
• W2023454919 cites W2139043745 @default.
• W2023454919 cites W2141444261 @default.
• W2023454919 cites W2150706412 @default.
• W2023454919 cites W2158950529 @default.
• W2023454919 cites W2159383827 @default.
• W2023454919 cites W2161154819 @default.
• W2023454919 cites W2161655320 @default.
• W2023454919 cites W2161807488 @default.
• W2023454919 cites W2169954069 @default.
• W2023454919 cites W2172047947 @default.
• W2023454919 cites W2315552227 @default.
• W2023454919 cites W2330005549 @default.
• W2023454919 cites W4251874594 @default.
• W2023454919 doi "https://doi.org/10.1002/dvdy.20883" @default.
• W2023454919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16894610" @default.
• W2023454919 hasPublicationYear "2006" @default.
• W2023454919 type Work @default.
• W2023454919 sameAs 2023454919 @default.
• W2023454919 citedByCount "29" @default.
• W2023454919 countsByYear W20234549192012 @default.
• W2023454919 countsByYear W20234549192013 @default.
• W2023454919 countsByYear W20234549192014 @default.
• W2023454919 countsByYear W20234549192015 @default.
• W2023454919 countsByYear W20234549192016 @default.
• W2023454919 countsByYear W20234549192018 @default.
• W2023454919 countsByYear W20234549192020 @default.
• W2023454919 countsByYear W20234549192021 @default.
• W2023454919 countsByYear W20234549192022 @default.
• W2023454919 countsByYear W20234549192023 @default.
• W2023454919 crossrefType "journal-article" @default.
• W2023454919 hasAuthorship W2023454919A5026837154 @default.
• W2023454919 hasAuthorship W2023454919A5056525986 @default.
• W2023454919 hasAuthorship W2023454919A5072720460 @default.
• W2023454919 hasAuthorship W2023454919A5073993996 @default.
• W2023454919 hasAuthorship W2023454919A5074887496 @default.
• W2023454919 hasAuthorship W2023454919A5087100546 @default.
• W2023454919 hasConcept C102309675 @default.
• W2023454919 hasConcept C104317684 @default.
• W2023454919 hasConcept C105702510 @default.
• W2023454919 hasConcept C126749454 @default.
• W2023454919 hasConcept C150194340 @default.
• W2023454919 hasConcept C153911025 @default.
• W2023454919 hasConcept C196843134 @default.
• W2023454919 hasConcept C2779329299 @default.
• W2023454919 hasConcept C2780594696 @default.
• W2023454919 hasConcept C54355233 @default.
• W2023454919 hasConcept C81439078 @default.
• W2023454919 hasConcept C86803240 @default.

• next