Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023455243> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2023455243 endingPage "126" @default.
- W2023455243 startingPage "120" @default.
- W2023455243 abstract "Abstract. Treatment of the acquired immunodeficiency syndrome with 3-azidothymidine (zidovudine; AZT) can induce severe neutropenia and anemia, while platelet counts increase. In order to understand the mechanism by which this favorable effect on platelets is induced, we prospectively studied platelet kinetics and platelet serology in 8 hemophiliacs receiving the drug. All patients underwent a second investigation after 3 months of treatment. Four patients were thrombocytopenic before treatment. Platelet counts increased significantly already after 1 week of treatment (p = 0.03), when only 3 patients remained thrombocytopenic. In these latter patients a further increase of platelet counts was noticed during the following 3 months. Platelet life-span was shortened in all patients at the initial investigation and a significant prolongation was measurable at the second evaluation (p = 0.015). Platelet-associated immunoglobulin G was increased in 3 patients at the first investigation and in 4 patients at the follow-up. Platelet-associated complement (PAC3d) was elevated in all subjects at the first determination. It decreased in 6, but increased in 2 patients thereafter; thus these changes did not become significant (p = 0.078). Immunofluorescence studies revealed antiplatelet antibodies in 7 patients' sera before treatment, and in 5 sera during drug therapy. At both investigations, the antibodies bound to the platelet glycoprotein IIIa as was demonstrated by immunoprecipitation of radiolabeled platelet proteins. We conclude, that AZT treatment improves platelet counts in HIV-infected hemophiliacs primarily by a prolongation of platelet survival without having a significant influence on antiplatelet antibody binding." @default.
- W2023455243 created "2016-06-24" @default.
- W2023455243 creator A5022092604 @default.
- W2023455243 creator A5027165619 @default.
- W2023455243 creator A5062933440 @default.
- W2023455243 creator A5083712588 @default.
- W2023455243 date "1989-09-01" @default.
- W2023455243 modified "2023-10-16" @default.
- W2023455243 title "Effects of 3-Azidothymidine on Platelet Counts, Indium-111-Labelled Platelet Kinetics, and Antiplatelet Antibodies" @default.
- W2023455243 cites W1972847637 @default.
- W2023455243 cites W1973254314 @default.
- W2023455243 cites W1991770499 @default.
- W2023455243 cites W1992654837 @default.
- W2023455243 cites W1996221727 @default.
- W2023455243 cites W1999446592 @default.
- W2023455243 cites W2001556535 @default.
- W2023455243 cites W2024719263 @default.
- W2023455243 cites W2029451526 @default.
- W2023455243 cites W2031034057 @default.
- W2023455243 cites W2037305132 @default.
- W2023455243 cites W2043704659 @default.
- W2023455243 cites W2046580453 @default.
- W2023455243 cites W2048297990 @default.
- W2023455243 cites W2052230769 @default.
- W2023455243 cites W2062555652 @default.
- W2023455243 cites W2066270367 @default.
- W2023455243 cites W2082706688 @default.
- W2023455243 cites W2090718632 @default.
- W2023455243 cites W2152700768 @default.
- W2023455243 cites W2163538506 @default.
- W2023455243 cites W2333399282 @default.
- W2023455243 cites W2398313758 @default.
- W2023455243 cites W2419944144 @default.
- W2023455243 cites W3148709400 @default.
- W2023455243 cites W330265897 @default.
- W2023455243 cites W4232251847 @default.
- W2023455243 cites W4256221661 @default.
- W2023455243 doi "https://doi.org/10.1111/j.1423-0410.1989.tb01148.x" @default.
- W2023455243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2675461" @default.
- W2023455243 hasPublicationYear "1989" @default.
- W2023455243 type Work @default.
- W2023455243 sameAs 2023455243 @default.
- W2023455243 citedByCount "5" @default.
- W2023455243 crossrefType "journal-article" @default.
- W2023455243 hasAuthorship W2023455243A5022092604 @default.
- W2023455243 hasAuthorship W2023455243A5027165619 @default.
- W2023455243 hasAuthorship W2023455243A5062933440 @default.
- W2023455243 hasAuthorship W2023455243A5083712588 @default.
- W2023455243 hasConcept C126322002 @default.
- W2023455243 hasConcept C159654299 @default.
- W2023455243 hasConcept C203014093 @default.
- W2023455243 hasConcept C2779771385 @default.
- W2023455243 hasConcept C2780216070 @default.
- W2023455243 hasConcept C2780727368 @default.
- W2023455243 hasConcept C3013748606 @default.
- W2023455243 hasConcept C45189115 @default.
- W2023455243 hasConcept C71924100 @default.
- W2023455243 hasConcept C89560881 @default.
- W2023455243 hasConcept C90924648 @default.
- W2023455243 hasConceptScore W2023455243C126322002 @default.
- W2023455243 hasConceptScore W2023455243C159654299 @default.
- W2023455243 hasConceptScore W2023455243C203014093 @default.
- W2023455243 hasConceptScore W2023455243C2779771385 @default.
- W2023455243 hasConceptScore W2023455243C2780216070 @default.
- W2023455243 hasConceptScore W2023455243C2780727368 @default.
- W2023455243 hasConceptScore W2023455243C3013748606 @default.
- W2023455243 hasConceptScore W2023455243C45189115 @default.
- W2023455243 hasConceptScore W2023455243C71924100 @default.
- W2023455243 hasConceptScore W2023455243C89560881 @default.
- W2023455243 hasConceptScore W2023455243C90924648 @default.
- W2023455243 hasIssue "2" @default.
- W2023455243 hasLocation W20234552431 @default.
- W2023455243 hasLocation W20234552432 @default.
- W2023455243 hasOpenAccess W2023455243 @default.
- W2023455243 hasPrimaryLocation W20234552431 @default.
- W2023455243 hasRelatedWork W108197325 @default.
- W2023455243 hasRelatedWork W177744588 @default.
- W2023455243 hasRelatedWork W1967199778 @default.
- W2023455243 hasRelatedWork W1981783160 @default.
- W2023455243 hasRelatedWork W2017250641 @default.
- W2023455243 hasRelatedWork W2067331360 @default.
- W2023455243 hasRelatedWork W2148345396 @default.
- W2023455243 hasRelatedWork W2398376574 @default.
- W2023455243 hasRelatedWork W2409507591 @default.
- W2023455243 hasRelatedWork W2464068520 @default.
- W2023455243 hasVolume "57" @default.
- W2023455243 isParatext "false" @default.
- W2023455243 isRetracted "false" @default.
- W2023455243 magId "2023455243" @default.
- W2023455243 workType "article" @default.