Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023456252> ?p ?o ?g. }
- W2023456252 endingPage "170" @default.
- W2023456252 startingPage "163" @default.
- W2023456252 abstract "Nanoparticles prepared with a blend of a biodegradable polyester (poly(-ε-caprolactone)) and a polycationic non-biodegradable acrylic polymer (Eudragit® RS) have been used as a drug carrier for oral administration of insulin. The rate of encapsulation of insulin was around 96%. The therapeutic efficiency of oral insulin nanoparticles (25, 50 and 100 IU/kg) in diabetic rats and the intestinal uptake of fluorescein isothiocyanate (FITC) labelled insulin were studied. When administered orally by force-feeding to diabetic rats, insulin nanoparticles decreased fasted glycemia in a dose dependant manner with a maximal effect observed with 100 IU/kg. These insulin nanoparticles also increased serum insulin levels and improved the glycemic response to an oral glucose challenge for a prolonged period of time. FITC-Insulin-loaded nanoparticles strongly adhered to the intestinal mucosa and labeled insulin, either released and/or still inside nanoparticles, was mainly taken up by the Peyer's patches. It is concluded that polymeric nanoparticles allows the preservation of insulin's biological activity. In addition, the antidiabetic effect can be explained by the mucoadhesive properties of the polycationic polymer (Eudragit® RS) allowing the intestinal uptake of insulin." @default.
- W2023456252 created "2016-06-24" @default.
- W2023456252 creator A5003109398 @default.
- W2023456252 creator A5041910052 @default.
- W2023456252 creator A5083076706 @default.
- W2023456252 date "2007-02-01" @default.
- W2023456252 modified "2023-10-11" @default.
- W2023456252 title "Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats" @default.
- W2023456252 cites W1485145206 @default.
- W2023456252 cites W1974020929 @default.
- W2023456252 cites W1974893668 @default.
- W2023456252 cites W1978125755 @default.
- W2023456252 cites W1992287346 @default.
- W2023456252 cites W2003688859 @default.
- W2023456252 cites W2012590274 @default.
- W2023456252 cites W2014779616 @default.
- W2023456252 cites W2027010214 @default.
- W2023456252 cites W2027437753 @default.
- W2023456252 cites W2029910396 @default.
- W2023456252 cites W2038683854 @default.
- W2023456252 cites W2047183738 @default.
- W2023456252 cites W2060851978 @default.
- W2023456252 cites W2061681190 @default.
- W2023456252 cites W2064173191 @default.
- W2023456252 cites W2064666752 @default.
- W2023456252 cites W2071590632 @default.
- W2023456252 cites W2073459275 @default.
- W2023456252 cites W2079208029 @default.
- W2023456252 cites W2087421919 @default.
- W2023456252 cites W2091918414 @default.
- W2023456252 cites W2103141876 @default.
- W2023456252 cites W2109835762 @default.
- W2023456252 cites W2119087638 @default.
- W2023456252 cites W2120169705 @default.
- W2023456252 cites W2133029248 @default.
- W2023456252 cites W2133856742 @default.
- W2023456252 cites W2142552924 @default.
- W2023456252 cites W2150729882 @default.
- W2023456252 cites W2167857098 @default.
- W2023456252 cites W2171071594 @default.
- W2023456252 cites W225447385 @default.
- W2023456252 cites W4246354161 @default.
- W2023456252 cites W84079184 @default.
- W2023456252 doi "https://doi.org/10.1016/j.jconrel.2006.10.023" @default.
- W2023456252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17141909" @default.
- W2023456252 hasPublicationYear "2007" @default.
- W2023456252 type Work @default.
- W2023456252 sameAs 2023456252 @default.
- W2023456252 citedByCount "316" @default.
- W2023456252 countsByYear W20234562522012 @default.
- W2023456252 countsByYear W20234562522013 @default.
- W2023456252 countsByYear W20234562522014 @default.
- W2023456252 countsByYear W20234562522015 @default.
- W2023456252 countsByYear W20234562522016 @default.
- W2023456252 countsByYear W20234562522017 @default.
- W2023456252 countsByYear W20234562522018 @default.
- W2023456252 countsByYear W20234562522019 @default.
- W2023456252 countsByYear W20234562522020 @default.
- W2023456252 countsByYear W20234562522021 @default.
- W2023456252 countsByYear W20234562522022 @default.
- W2023456252 countsByYear W20234562522023 @default.
- W2023456252 crossrefType "journal-article" @default.
- W2023456252 hasAuthorship W2023456252A5003109398 @default.
- W2023456252 hasAuthorship W2023456252A5041910052 @default.
- W2023456252 hasAuthorship W2023456252A5083076706 @default.
- W2023456252 hasConcept C121332964 @default.
- W2023456252 hasConcept C126322002 @default.
- W2023456252 hasConcept C13245373 @default.
- W2023456252 hasConcept C134018914 @default.
- W2023456252 hasConcept C155672457 @default.
- W2023456252 hasConcept C171250308 @default.
- W2023456252 hasConcept C178790620 @default.
- W2023456252 hasConcept C185592680 @default.
- W2023456252 hasConcept C192562407 @default.
- W2023456252 hasConcept C2777019933 @default.
- W2023456252 hasConcept C2777056448 @default.
- W2023456252 hasConcept C2779306644 @default.
- W2023456252 hasConcept C2779820397 @default.
- W2023456252 hasConcept C2780473172 @default.
- W2023456252 hasConcept C45211672 @default.
- W2023456252 hasConcept C521977710 @default.
- W2023456252 hasConcept C555293320 @default.
- W2023456252 hasConcept C62520636 @default.
- W2023456252 hasConcept C71924100 @default.
- W2023456252 hasConcept C77281830 @default.
- W2023456252 hasConcept C91881484 @default.
- W2023456252 hasConcept C98274493 @default.
- W2023456252 hasConceptScore W2023456252C121332964 @default.
- W2023456252 hasConceptScore W2023456252C126322002 @default.
- W2023456252 hasConceptScore W2023456252C13245373 @default.
- W2023456252 hasConceptScore W2023456252C134018914 @default.
- W2023456252 hasConceptScore W2023456252C155672457 @default.
- W2023456252 hasConceptScore W2023456252C171250308 @default.
- W2023456252 hasConceptScore W2023456252C178790620 @default.
- W2023456252 hasConceptScore W2023456252C185592680 @default.
- W2023456252 hasConceptScore W2023456252C192562407 @default.
- W2023456252 hasConceptScore W2023456252C2777019933 @default.
- W2023456252 hasConceptScore W2023456252C2777056448 @default.