FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023457194> ?p ?o ?g. }

• W2023457194 endingPage "164" @default.
• W2023457194 startingPage "153" @default.
• W2023457194 abstract "Whole cell voltage and current clamp recordings were obtained from third order neurons isolated from the salamander retina. Using cross desensitization, the structure-function relationship of short chain amino acids on the glycine receptor were examined. L-Serine, L-alanine, beta-alanine and taurine all cross desensitized with glycine, but did not show significant cross desensitization with GABA. This indicates that these amino acids act at the glycine receptor. The order of potency was glycine >> beta-alanine > taurine >> L-alanine > L-serine. TAG, a reputed selective taurine antagonist, was equally effective in blocking taurine and glycine currents. There is no evidence for distinct receptors for taurine. Amino acids with larger moieties at the alpha carbon, such as threonine and valine, produced inactive ligands. Placing a methyl group on the amine of glycine or esterification of the carboxyl group also greatly reduced activity. Based on these modifications of the glycine molecule, it appears that selectivity at the glycine receptor results in part from steric restrictions at all three sites in the glycine chain. The steric interference is most critical at the carboxyl and amino ends, and less limiting at the alpha carbon. Doses of L-serine that had only slight effects in voltage clamp experiments, nevertheless produced large effects in current clamp experiments. This indicates that several endogenous amino acids can have significant effects on membrane voltage, even when their shunting activity may be small. High concentrations of agonists produced desensitization in the voltage clamp records, but there was little evidence of desensitization in the current clamp experiments. These results indicate that several endogenous amino acids can activate the glycine receptor, but there is no evidence for a discrete receptor for taurine, beta-alanine, L-alanine or L-serine. Since all these endogenous amino acids have similar amino and acid terminals, reduction in potency results from steric interference around the alpha carbon. This graded potency may have functional significance in mediating inhibition." @default.
• W2023457194 created "2016-06-24" @default.
• W2023457194 creator A5012714151 @default.
• W2023457194 creator A5021402564 @default.
• W2023457194 date "1995-01-01" @default.
• W2023457194 modified "2023-09-30" @default.
• W2023457194 title "Comparison of the actions of glycine and related amino acids on isolated third order neurons from the tiger salamander retina" @default.
• W2023457194 cites W1488934481 @default.
• W2023457194 cites W1964897006 @default.
• W2023457194 cites W1967490873 @default.
• W2023457194 cites W1971340815 @default.
• W2023457194 cites W1973887584 @default.
• W2023457194 cites W1979569981 @default.
• W2023457194 cites W1979845443 @default.
• W2023457194 cites W1986210298 @default.
• W2023457194 cites W1986315354 @default.
• W2023457194 cites W1987134434 @default.
• W2023457194 cites W1989987157 @default.
• W2023457194 cites W1990546626 @default.
• W2023457194 cites W1992634444 @default.
• W2023457194 cites W1993024292 @default.
• W2023457194 cites W1998845069 @default.
• W2023457194 cites W2030047965 @default.
• W2023457194 cites W2040081736 @default.
• W2023457194 cites W2043863538 @default.
• W2023457194 cites W2046586729 @default.
• W2023457194 cites W2061342519 @default.
• W2023457194 cites W2069097002 @default.
• W2023457194 cites W2070147043 @default.
• W2023457194 cites W2079092365 @default.
• W2023457194 cites W2081678712 @default.
• W2023457194 cites W2093811657 @default.
• W2023457194 cites W2094244891 @default.
• W2023457194 cites W2114089489 @default.
• W2023457194 cites W2146351232 @default.
• W2023457194 cites W2147974991 @default.
• W2023457194 cites W2395085343 @default.
• W2023457194 cites W2409170450 @default.
• W2023457194 cites W2411545912 @default.
• W2023457194 cites W2412524679 @default.
• W2023457194 cites W5013036 @default.
• W2023457194 cites W2060070878 @default.
• W2023457194 doi "https://doi.org/10.1016/0306-4522(94)00399-p" @default.
• W2023457194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7708201" @default.
• W2023457194 hasPublicationYear "1995" @default.
• W2023457194 type Work @default.
• W2023457194 sameAs 2023457194 @default.
• W2023457194 citedByCount "21" @default.
• W2023457194 countsByYear W20234571942012 @default.
• W2023457194 countsByYear W20234571942013 @default.
• W2023457194 countsByYear W20234571942017 @default.
• W2023457194 countsByYear W20234571942019 @default.
• W2023457194 crossrefType "journal-article" @default.
• W2023457194 hasAuthorship W2023457194A5012714151 @default.
• W2023457194 hasAuthorship W2023457194A5021402564 @default.
• W2023457194 hasConcept C100837961 @default.
• W2023457194 hasConcept C12554922 @default.
• W2023457194 hasConcept C170493617 @default.
• W2023457194 hasConcept C181199279 @default.
• W2023457194 hasConcept C181911157 @default.
• W2023457194 hasConcept C185592680 @default.
• W2023457194 hasConcept C2776414213 @default.
• W2023457194 hasConcept C2777573094 @default.
• W2023457194 hasConcept C2777756961 @default.
• W2023457194 hasConcept C2779701627 @default.
• W2023457194 hasConcept C2779779143 @default.
• W2023457194 hasConcept C2779856020 @default.
• W2023457194 hasConcept C35599011 @default.
• W2023457194 hasConcept C515207424 @default.
• W2023457194 hasConcept C55493867 @default.
• W2023457194 hasConcept C86803240 @default.
• W2023457194 hasConceptScore W2023457194C100837961 @default.
• W2023457194 hasConceptScore W2023457194C12554922 @default.
• W2023457194 hasConceptScore W2023457194C170493617 @default.
• W2023457194 hasConceptScore W2023457194C181199279 @default.
• W2023457194 hasConceptScore W2023457194C181911157 @default.
• W2023457194 hasConceptScore W2023457194C185592680 @default.
• W2023457194 hasConceptScore W2023457194C2776414213 @default.
• W2023457194 hasConceptScore W2023457194C2777573094 @default.
• W2023457194 hasConceptScore W2023457194C2777756961 @default.
• W2023457194 hasConceptScore W2023457194C2779701627 @default.
• W2023457194 hasConceptScore W2023457194C2779779143 @default.
• W2023457194 hasConceptScore W2023457194C2779856020 @default.
• W2023457194 hasConceptScore W2023457194C35599011 @default.
• W2023457194 hasConceptScore W2023457194C515207424 @default.
• W2023457194 hasConceptScore W2023457194C55493867 @default.
• W2023457194 hasConceptScore W2023457194C86803240 @default.
• W2023457194 hasIssue "1" @default.
• W2023457194 hasLocation W20234571941 @default.
• W2023457194 hasLocation W20234571942 @default.
• W2023457194 hasOpenAccess W2023457194 @default.
• W2023457194 hasPrimaryLocation W20234571941 @default.
• W2023457194 hasRelatedWork W1989032592 @default.
• W2023457194 hasRelatedWork W1992713633 @default.
• W2023457194 hasRelatedWork W2046782971 @default.
• W2023457194 hasRelatedWork W2049748437 @default.
• W2023457194 hasRelatedWork W2162705792 @default.
• W2023457194 hasRelatedWork W2313390970 @default.

• next