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- W2023457785 abstract "This work aims to study the influence of H-2 locus in the control of Leishmania infantum infection by evaluating whether cytokine responses by host macrophages of different H-2 haplotype are differentially regulated, either induced or actively impaired during parasite growth and replication. This study shows that macrophages of “non-cure” phenotype (H-2d) are more susceptible to infection with virulent L. infantum promastigotes. Virulent parasites lead to impaired IL-12 and inhibited TNF-α expression. The degree of parasite virulence is an important contributing factor to differences detected in cytokine expression. Virulent parasites also induced TGF-β, a deactivating cytokine that is known to suppress Th-1 type responses, thus allowing the parasite to subvert antimicrobial activity and increase its chances of survival. Depending on specific host haplotype, cells differentially respond to infection since TNF-α expression is inhibited and TGF-β is enhanced by macrophages of “non-cure” phenotype, thus perhaps determining their degree of susceptibility in this strain of mice." @default.
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- W2023457785 date "2006-10-01" @default.
- W2023457785 modified "2023-09-23" @default.
- W2023457785 title "H-2 complex influences cytokine gene expression in Leishmania infantum-infected macrophages" @default.
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- W2023457785 doi "https://doi.org/10.1016/j.cellimm.2007.01.005" @default.
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