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• W2023458060 endingPage "e64836" @default.
• W2023458060 startingPage "e64836" @default.
• W2023458060 abstract "In African endemic area, adults are less vulnerable to cerebral malaria than children probably because of acquired partial immunity or semi-immune status. Here, we developed an experimental cerebral malaria (ECM) model for semi-immune mice. C57BL/6 (B6) mice underwent one, two and three cycles of infection and radical treatment (1-cure, 2-cure and 3-cure, respectively) before being finally challenged with 10(4) Plasmodium berghei ANKA without treatment. Our results showed that 100% of naïve (0-cure), 67% of 1-cure, 37% of 2-cure and none of 3-cure mice succumbed to ECM within 10 days post challenge infection. In the protected 3-cure mice, significantly higher levels of plasma IL-10 and lower levels of IFN-γ than the others on day 7 post challenge infection were observed. Major increased lymphocyte subset of IL-10 positive cells in 3-cure mice was CD5(-)CD19(+) B cells. Passive transfer of splenic CD19(+) cells from 3-cure mice protected naïve mice from ECM. Additionally, aged 3-cure mice were also protected from ECM 12 and 20 months after the last challenge infection. In conclusion, mice became completely resistant to ECM after three exposures to malaria. CD19(+) B cells are determinants in protective mechanism of semi-immune mice against ECM possibly via modulatory IL-10 for pathogenic IFN-γ production." @default.
• W2023458060 created "2016-06-24" @default.
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• W2023458060 date "2013-05-28" @default.
• W2023458060 modified "2023-10-04" @default.
• W2023458060 title "CD19(+) B Cells Confer Protection against Experimental Cerebral Malaria in Semi-Immune Rodent Model" @default.
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• W2023458060 doi "https://doi.org/10.1371/journal.pone.0064836" @default.
• W2023458060 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3665539" @default.
• W2023458060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23724100" @default.
• W2023458060 hasPublicationYear "2013" @default.
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