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- W2023459737 abstract "PurposeCorrection of dentofacial deformities by orthognathic surgery may cause significant bleeding and therefore hypotensive anesthesia is often used to reduce the blood loss. The main objective of the present clinical study was to determine whether the addition of hemorrhage depressors to other medication during orthognathic surgery would further reduce the blood loss.Patients and methodsThirty patients, consecutively operated on with standardized Le Fort I osteotomies in 1998 (n = 15, control group) and 1999 (n = 15, treatment group), were included in the study. Both groups received hypotension anesthesia during surgery and the treatment group received additional hemorrhage depressors; tranexamic acid and desmopressin.ResultsThe mean blood loss was 740 ± 410 mL (11.3 mL/kg) in the control group and 400 ± 210 mL (5.7 mL/kg) in the treatment group. The results showed a statistically significant reduction of blood loss in the treatment group (P < .01).ConclusionsThis study shows that blood loss during orthognathic surgery under hypotensive anesthesia can be significantly reduced when a combination of tranexamic acid and desmopressin is added." @default.
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- W2023459737 date "2004-06-01" @default.
- W2023459737 modified "2023-10-17" @default.
- W2023459737 title "Evaluation of hemorrhage depressors on blood loss during orthognathic surgery: a retrospective study" @default.
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- W2023459737 doi "https://doi.org/10.1016/j.joms.2004.02.001" @default.
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