FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023459898> ?p ?o ?g. }

• W2023459898 endingPage "6717" @default.
• W2023459898 startingPage "6712" @default.
• W2023459898 abstract "Natural and synthetic agonists of the peroxisome proliferator-activated receptor gamma (PPARgamma) regulate adipocyte differentiation, glucose homeostasis, and inflammatory responses. Although effects on adipogenesis and glucose metabolism are genetically linked to PPARgamma, the PPARgamma dependence of antiinflammatory responses of these substances is less clear. Here, we have used a combination of mRNA expression profiling and conditional disruption of the PPARgamma gene in mice to characterize programs of transcriptional activation and repression by PPARgamma agonists in elicited peritoneal macrophages. Natural and synthetic PPARgamma agonists, including the thiazolidinedione rosiglitazone (Ro), modestly induced the expression of a surprisingly small number of genes, several of which were also induced by a specific PPARdelta agonist. The majority of these genes encode proteins involved in lipid homeostasis. In contrast, Ro inhibited induction of broad subsets of lipopolysaccharide and IFN-gamma target genes in a gene-specific and PPARgamma-dependent manner. At high concentrations, Ro inhibited induction of lipopolysaccharide target genes in PPARgamma-deficient macrophages, at least in part by activating PPARdelta. These studies establish overlapping transactivation and transrepression functions of PPARgamma and PPARdelta in macrophages and suggest that a major transcriptional role of PPARgamma is negative regulation of specific subsets of genes that are activated by T helper 1 cytokines and pathogenic molecules that signal through pattern recognition receptors. These findings support a physiological role of PPARgamma in regulating both native and acquired immune responses." @default.
• W2023459898 created "2016-06-24" @default.
• W2023459898 creator A5017593302 @default.
• W2023459898 creator A5039839135 @default.
• W2023459898 creator A5056334182 @default.
• W2023459898 creator A5073932699 @default.
• W2023459898 creator A5081851296 @default.
• W2023459898 date "2003-05-09" @default.
• W2023459898 modified "2023-10-14" @default.
• W2023459898 title "PPARγ and PPARδ negatively regulate specific subsets of lipopolysaccharide and IFN-γ target genes in macrophages" @default.
• W2023459898 cites W1494611500 @default.
• W2023459898 cites W1505047300 @default.
• W2023459898 cites W1524478189 @default.
• W2023459898 cites W1539079080 @default.
• W2023459898 cites W1633340712 @default.
• W2023459898 cites W1639924204 @default.
• W2023459898 cites W1656162023 @default.
• W2023459898 cites W1812573520 @default.
• W2023459898 cites W1951826532 @default.
• W2023459898 cites W1969176613 @default.
• W2023459898 cites W1973208496 @default.
• W2023459898 cites W1976621212 @default.
• W2023459898 cites W1986256219 @default.
• W2023459898 cites W1987052134 @default.
• W2023459898 cites W1993730176 @default.
• W2023459898 cites W1995398218 @default.
• W2023459898 cites W1996267589 @default.
• W2023459898 cites W2003115027 @default.
• W2023459898 cites W2005674716 @default.
• W2023459898 cites W2006574739 @default.
• W2023459898 cites W2021758696 @default.
• W2023459898 cites W2046747192 @default.
• W2023459898 cites W2050717908 @default.
• W2023459898 cites W2059895383 @default.
• W2023459898 cites W2063305853 @default.
• W2023459898 cites W2071304121 @default.
• W2023459898 cites W2079080809 @default.
• W2023459898 cites W2080000513 @default.
• W2023459898 cites W2086040049 @default.
• W2023459898 cites W2087647782 @default.
• W2023459898 cites W2097314900 @default.
• W2023459898 cites W2115837052 @default.
• W2023459898 cites W2125344994 @default.
• W2023459898 cites W2132070369 @default.
• W2023459898 cites W2133941138 @default.
• W2023459898 cites W2144473903 @default.
• W2023459898 cites W2157393124 @default.
• W2023459898 cites W2158969881 @default.
• W2023459898 cites W2159742257 @default.
• W2023459898 cites W2164367541 @default.
• W2023459898 cites W2168332555 @default.
• W2023459898 cites W4239629847 @default.
• W2023459898 cites W4313050937 @default.
• W2023459898 doi "https://doi.org/10.1073/pnas.1031789100" @default.
• W2023459898 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/164512" @default.
• W2023459898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12740443" @default.
• W2023459898 hasPublicationYear "2003" @default.
• W2023459898 type Work @default.
• W2023459898 sameAs 2023459898 @default.
• W2023459898 citedByCount "408" @default.
• W2023459898 countsByYear W20234598982012 @default.
• W2023459898 countsByYear W20234598982013 @default.
• W2023459898 countsByYear W20234598982014 @default.
• W2023459898 countsByYear W20234598982015 @default.
• W2023459898 countsByYear W20234598982016 @default.
• W2023459898 countsByYear W20234598982017 @default.
• W2023459898 countsByYear W20234598982018 @default.
• W2023459898 countsByYear W20234598982019 @default.
• W2023459898 countsByYear W20234598982020 @default.
• W2023459898 countsByYear W20234598982021 @default.
• W2023459898 countsByYear W20234598982022 @default.
• W2023459898 countsByYear W20234598982023 @default.
• W2023459898 crossrefType "journal-article" @default.
• W2023459898 hasAuthorship W2023459898A5017593302 @default.
• W2023459898 hasAuthorship W2023459898A5039839135 @default.
• W2023459898 hasAuthorship W2023459898A5056334182 @default.
• W2023459898 hasAuthorship W2023459898A5073932699 @default.
• W2023459898 hasAuthorship W2023459898A5081851296 @default.
• W2023459898 hasBestOaLocation W20234598981 @default.
• W2023459898 hasConcept C104317684 @default.
• W2023459898 hasConcept C122927707 @default.
• W2023459898 hasConcept C1292079 @default.
• W2023459898 hasConcept C134018914 @default.
• W2023459898 hasConcept C14093617 @default.
• W2023459898 hasConcept C150194340 @default.
• W2023459898 hasConcept C170493617 @default.
• W2023459898 hasConcept C187345961 @default.
• W2023459898 hasConcept C2777391703 @default.
• W2023459898 hasConcept C2778754761 @default.
• W2023459898 hasConcept C2779306644 @default.
• W2023459898 hasConcept C2780152017 @default.
• W2023459898 hasConcept C3018667095 @default.
• W2023459898 hasConcept C55493867 @default.
• W2023459898 hasConcept C59300778 @default.
• W2023459898 hasConcept C63932345 @default.
• W2023459898 hasConcept C86339819 @default.
• W2023459898 hasConcept C86803240 @default.
• W2023459898 hasConcept C95444343 @default.

• next