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- W2023460010 abstract "Abstract Introduction: Myotonic dystrophy, or dystrophia myotonica (DM), is characterized by prominent muscle wasting and weakness as well as delayed muscle relaxation resulting from persistent electrical discharges. Methods: We hypothesized heterogeneity among muscles in degree of weakness and myotonia in an expanded [(CUG) 250 ] repeats transgenic ( HSA LR ) mouse DM model. Muscle contraction was compared among diaphragm, extensor digitorum longus (EDL), and soleus muscles. Results: Myotonia was found only in EDL, as manifested by longer late‐relaxation time and elevated myotonic index. EDL, but not the other two muscles, had impaired force over a wide range of stimulation frequencies. During fatigue‐inducing stimulation, DM EDL muscle force per cross‐sectional area was significantly impaired during 25‐Hz stimulation, whereas there were no differences in fatigue response for DM diaphragm or soleus. Conclusion: In an expanded repeats model of DM the EDL is more susceptible to myotonia and force impairment than muscles with lower proportions of fast‐twitch fibers. Muscle Nerve, 2011" @default.
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- W2023460010 date "2011-03-14" @default.
- W2023460010 modified "2023-10-18" @default.
- W2023460010 title "Differential susceptibility of muscles to myotonia and force impairment in a mouse model of myotonic dystrophy" @default.
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- W2023460010 doi "https://doi.org/10.1002/mus.21988" @default.
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