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• W2023461213 endingPage "e1003017" @default.
• W2023461213 startingPage "e1003017" @default.
• W2023461213 abstract "Considerable evidence now supports the idea that the moderate telomere lengthening produced by recombinational telomere elongation (RTE) in a Kluyveromyces lactis telomerase deletion mutant occurs through a roll-and-spread mechanism. However, it is unclear whether this mechanism can account for other forms of RTE that produce much longer telomeres such as are seen in human alternative lengthening of telomere (ALT) cells or in the telomerase-resistant type IIR “runaway” RTE such as occurs in the K. lactis stn1-M1 mutant. In this study we have used mutationally tagged telomeres to examine the mechanism of RTE in an stn1-M1 mutant both with and without telomerase. Our results suggest that the establishment stage of the mutant state in newly generated stn1-M1 ter1-Δ mutants surprisingly involves a first stage of sudden telomere shortening. Our data also show that, as predicted by the roll-and-spread mechanism, all lengthened telomeres in a newly established mutant cell commonly emerge from a single telomere source. However, in sharp contrast to the RTE of telomerase deletion survivors, we show that the RTE of stn1-M1 ter1-Δ cells produces telomeres whose sequences undergo continuous intense scrambling via recombination. While telomerase was not necessary for the long telomeres in stn1-M1 cells, its presence during their establishment was seen to interfere with the amplification of repeats via recombination, a result consistent with telomerase retaining its ability to add repeats during active RTE. Finally, we observed that the presence of active mismatch repair or telomerase had important influences on telomeric amplification and/or instability." @default.
• W2023461213 created "2016-06-24" @default.
• W2023461213 creator A5025211550 @default.
• W2023461213 creator A5080898109 @default.
• W2023461213 date "2012-11-01" @default.
• W2023461213 modified "2023-09-23" @default.
• W2023461213 title "Long Telomeres Produced by Telomerase-Resistant Recombination Are Established from a Single Source and Are Subject to Extreme Sequence Scrambling" @default.
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• W2023461213 doi "https://doi.org/10.1371/journal.pgen.1003017" @default.
• W2023461213 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3486848" @default.
• W2023461213 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23133400" @default.
• W2023461213 hasPublicationYear "2012" @default.
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