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- W2023461772 abstract "It is proposed in the present communication to present the results of investigations bearing on the nature of those remarkable structures known as “Plimmer’s Bodies.” As is well known, these are found in many cancerous growths, and are most commonly encountered in the younger or growing regions of the tumour. They appear in the form of vesicles, and they consist essentially of a fairly well-defined wall containing a clear space in which is suspended a small darkly staining granule (figs. 1, 2, and 3). They are most commonly to be met with in tumours of a glandular or glandular-epithelial origin They lie in the cytoplasm of the cancer cell, and usually in close proximity to the nucleus. In size, they vary from excessive minuteness to that of the nucleus itself. The special interest attaching to them depends on the fact that they have commonly been regarded as peculiar to cancerous cells, although Honda believes he has occasionally also encountered them in inflammatory tissues.They have been variously interpreted. Some investigators have regarded them as parasitic organisms, more or less intimately connected - with the etiology of the disease, whilst others have seen in them a differentiation of the cytoplasm of the cancerous cell itself. It has been suggested also that they might be derived from the centrosomes within the archoplasm, but the observations of Benda; that centrosomes coexisted independently of them in the cell, has rightly been held to disprove this hypothesis." @default.
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- W2023461772 date "1905-06-28" @default.
- W2023461772 modified "2023-09-27" @default.
- W2023461772 title "On the resemblances existing between the “Plimmer's Bodies” of malignant growths,and certain normal constituents of reproductive cells of animals" @default.
- W2023461772 doi "https://doi.org/10.1098/rspb.1905.0015" @default.
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