Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023462803> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2023462803 endingPage "30" @default.
- W2023462803 startingPage "25" @default.
- W2023462803 abstract "The human prion encephalopathy Creutzfeldt-Jakob disease often is manifest as rapidly progressing dementia with myoclonus and synchronous, periodic discharges. To investigate the electrophysiology of prion disease we used intra- and extra-cellular recordings from brain slices from Tg(SHaPrP+/+) 81 mice, which express Syrian hamster prion protein and which are susceptible to hamster-passaged scrapie isolates. Forty days after intracerebral inoculation with scrapie isolate Sc237, we recorded prolonged, epileptiform discharges in cortex and hippocampus. Neurological signs were subtle and histopathology was minimal. Central nervous system (CNS) dysfunction progressed; by 57 days the mice were ataxic, had spongiform histopathology and they died in <63 days. During the terminal phase, intrinsic neuronal properties changed dramatically and action potentials broadened from <4 to 20–100 ms in 30% of cortical cells. We conclude that brain dysfunction in experimental scrapie precedes clinical signs and spongiform histopathology, and is preserved in slices maintainedin vitro, making it accessible to electrophysiological analysis." @default.
- W2023462803 created "2016-06-24" @default.
- W2023462803 creator A5000878141 @default.
- W2023462803 creator A5022994404 @default.
- W2023462803 creator A5055890012 @default.
- W2023462803 creator A5066991343 @default.
- W2023462803 date "1994-11-01" @default.
- W2023462803 modified "2023-09-23" @default.
- W2023462803 title "Scrapie infection of transgenic mice leads to network and intrinsic dysfunction of cortical and hippocampal neurones" @default.
- W2023462803 doi "https://doi.org/10.1006/nbdi.1994.0004" @default.
- W2023462803 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9216983" @default.
- W2023462803 hasPublicationYear "1994" @default.
- W2023462803 type Work @default.
- W2023462803 sameAs 2023462803 @default.
- W2023462803 citedByCount "32" @default.
- W2023462803 countsByYear W20234628032014 @default.
- W2023462803 crossrefType "journal-article" @default.
- W2023462803 hasAuthorship W2023462803A5000878141 @default.
- W2023462803 hasAuthorship W2023462803A5022994404 @default.
- W2023462803 hasAuthorship W2023462803A5055890012 @default.
- W2023462803 hasAuthorship W2023462803A5066991343 @default.
- W2023462803 hasConcept C102230213 @default.
- W2023462803 hasConcept C104317684 @default.
- W2023462803 hasConcept C134018914 @default.
- W2023462803 hasConcept C141035611 @default.
- W2023462803 hasConcept C142724271 @default.
- W2023462803 hasConcept C148762608 @default.
- W2023462803 hasConcept C159047783 @default.
- W2023462803 hasConcept C169760540 @default.
- W2023462803 hasConcept C185263204 @default.
- W2023462803 hasConcept C2776538686 @default.
- W2023462803 hasConcept C2776735649 @default.
- W2023462803 hasConcept C2776797465 @default.
- W2023462803 hasConcept C2776925932 @default.
- W2023462803 hasConcept C2777682930 @default.
- W2023462803 hasConcept C2778575167 @default.
- W2023462803 hasConcept C2779134260 @default.
- W2023462803 hasConcept C2781041448 @default.
- W2023462803 hasConcept C2781161787 @default.
- W2023462803 hasConcept C3019804061 @default.
- W2023462803 hasConcept C529278444 @default.
- W2023462803 hasConcept C544855455 @default.
- W2023462803 hasConcept C55493867 @default.
- W2023462803 hasConcept C71924100 @default.
- W2023462803 hasConcept C86803240 @default.
- W2023462803 hasConceptScore W2023462803C102230213 @default.
- W2023462803 hasConceptScore W2023462803C104317684 @default.
- W2023462803 hasConceptScore W2023462803C134018914 @default.
- W2023462803 hasConceptScore W2023462803C141035611 @default.
- W2023462803 hasConceptScore W2023462803C142724271 @default.
- W2023462803 hasConceptScore W2023462803C148762608 @default.
- W2023462803 hasConceptScore W2023462803C159047783 @default.
- W2023462803 hasConceptScore W2023462803C169760540 @default.
- W2023462803 hasConceptScore W2023462803C185263204 @default.
- W2023462803 hasConceptScore W2023462803C2776538686 @default.
- W2023462803 hasConceptScore W2023462803C2776735649 @default.
- W2023462803 hasConceptScore W2023462803C2776797465 @default.
- W2023462803 hasConceptScore W2023462803C2776925932 @default.
- W2023462803 hasConceptScore W2023462803C2777682930 @default.
- W2023462803 hasConceptScore W2023462803C2778575167 @default.
- W2023462803 hasConceptScore W2023462803C2779134260 @default.
- W2023462803 hasConceptScore W2023462803C2781041448 @default.
- W2023462803 hasConceptScore W2023462803C2781161787 @default.
- W2023462803 hasConceptScore W2023462803C3019804061 @default.
- W2023462803 hasConceptScore W2023462803C529278444 @default.
- W2023462803 hasConceptScore W2023462803C544855455 @default.
- W2023462803 hasConceptScore W2023462803C55493867 @default.
- W2023462803 hasConceptScore W2023462803C71924100 @default.
- W2023462803 hasConceptScore W2023462803C86803240 @default.
- W2023462803 hasIssue "1-2" @default.
- W2023462803 hasLocation W20234628031 @default.
- W2023462803 hasLocation W20234628032 @default.
- W2023462803 hasOpenAccess W2023462803 @default.
- W2023462803 hasPrimaryLocation W20234628031 @default.
- W2023462803 hasRelatedWork W1505059619 @default.
- W2023462803 hasRelatedWork W1617122023 @default.
- W2023462803 hasRelatedWork W2015549810 @default.
- W2023462803 hasRelatedWork W2023462803 @default.
- W2023462803 hasRelatedWork W2035629807 @default.
- W2023462803 hasRelatedWork W2121611717 @default.
- W2023462803 hasRelatedWork W2137375748 @default.
- W2023462803 hasRelatedWork W2384671041 @default.
- W2023462803 hasRelatedWork W2418735187 @default.
- W2023462803 hasRelatedWork W2184905977 @default.
- W2023462803 hasVolume "1" @default.
- W2023462803 isParatext "false" @default.
- W2023462803 isRetracted "false" @default.
- W2023462803 magId "2023462803" @default.
- W2023462803 workType "article" @default.