FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023463516> ?p ?o ?g. }

• W2023463516 endingPage "10762" @default.
• W2023463516 startingPage "10758" @default.
• W2023463516 abstract "We have isolated a cDNA from a mouse brain library that encodes a protein whose predicted amino acid sequence is 42% identical and 64% similar to that of the amyloid beta protein precursor (APP). This 653-amino acid protein, which we have termed the amyloid precursor-like protein (APLP), appears to be similar to APP in overall structure as well as amino acid sequence. The amino acid homologies are concentrated within three distinct regions of the two proteins where the identities are 47%, 54%, and 56%. The APLP cDNA hybridizes to two messages of approximately 2.4 and 1.6 kilobases that are present in mouse brain and neuroblastoma cells. Polyclonal antibodies raised against a peptide derived from the C terminus of APLP stain the cytoplasm in a pattern reminiscent of Golgi staining. In addition to APP, APLP also displays significant homology to the Drosophila APP-like protein APPL and a rat testes APP-like protein. These data indicate that the APP gene is a member of a strongly conserved gene family. Studies aimed at determining the functions of the proteins encoded by this gene family should provide valuable clues to their potential role in Alzheimer disease neuropathology." @default.
• W2023463516 created "2016-06-24" @default.
• W2023463516 creator A5022200766 @default.
• W2023463516 creator A5030541168 @default.
• W2023463516 creator A5044329623 @default.
• W2023463516 creator A5047177278 @default.
• W2023463516 creator A5049485062 @default.
• W2023463516 creator A5050004777 @default.
• W2023463516 date "1992-11-15" @default.
• W2023463516 modified "2023-10-11" @default.
• W2023463516 title "Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor." @default.
• W2023463516 cites W1215372462 @default.
• W2023463516 cites W1521304851 @default.
• W2023463516 cites W1577594918 @default.
• W2023463516 cites W1607784649 @default.
• W2023463516 cites W1804602231 @default.
• W2023463516 cites W1882078023 @default.
• W2023463516 cites W1964581847 @default.
• W2023463516 cites W1970796584 @default.
• W2023463516 cites W1979240613 @default.
• W2023463516 cites W1984730682 @default.
• W2023463516 cites W1985791105 @default.
• W2023463516 cites W2009105413 @default.
• W2023463516 cites W2013803304 @default.
• W2023463516 cites W2014669590 @default.
• W2023463516 cites W2017957082 @default.
• W2023463516 cites W2022446410 @default.
• W2023463516 cites W2026201438 @default.
• W2023463516 cites W2038012168 @default.
• W2023463516 cites W2038086035 @default.
• W2023463516 cites W2038516967 @default.
• W2023463516 cites W2046389334 @default.
• W2023463516 cites W2056046302 @default.
• W2023463516 cites W2063231418 @default.
• W2023463516 cites W2064093411 @default.
• W2023463516 cites W2069682857 @default.
• W2023463516 cites W2071691905 @default.
• W2023463516 cites W2074492469 @default.
• W2023463516 cites W2075455405 @default.
• W2023463516 cites W2081881251 @default.
• W2023463516 cites W2084015178 @default.
• W2023463516 cites W2091149521 @default.
• W2023463516 cites W2091505182 @default.
• W2023463516 cites W2096488371 @default.
• W2023463516 cites W2108388593 @default.
• W2023463516 cites W2113305211 @default.
• W2023463516 cites W2137091249 @default.
• W2023463516 cites W2410361929 @default.
• W2023463516 cites W2576734941 @default.
• W2023463516 doi "https://doi.org/10.1073/pnas.89.22.10758" @default.
• W2023463516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/50421" @default.
• W2023463516 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1279693" @default.
• W2023463516 hasPublicationYear "1992" @default.
• W2023463516 type Work @default.
• W2023463516 sameAs 2023463516 @default.
• W2023463516 citedByCount "361" @default.
• W2023463516 countsByYear W20234635162012 @default.
• W2023463516 countsByYear W20234635162013 @default.
• W2023463516 countsByYear W20234635162014 @default.
• W2023463516 countsByYear W20234635162015 @default.
• W2023463516 countsByYear W20234635162016 @default.
• W2023463516 countsByYear W20234635162017 @default.
• W2023463516 countsByYear W20234635162018 @default.
• W2023463516 countsByYear W20234635162019 @default.
• W2023463516 countsByYear W20234635162020 @default.
• W2023463516 countsByYear W20234635162021 @default.
• W2023463516 countsByYear W20234635162022 @default.
• W2023463516 countsByYear W20234635162023 @default.
• W2023463516 crossrefType "journal-article" @default.
• W2023463516 hasAuthorship W2023463516A5022200766 @default.
• W2023463516 hasAuthorship W2023463516A5030541168 @default.
• W2023463516 hasAuthorship W2023463516A5044329623 @default.
• W2023463516 hasAuthorship W2023463516A5047177278 @default.
• W2023463516 hasAuthorship W2023463516A5049485062 @default.
• W2023463516 hasAuthorship W2023463516A5050004777 @default.
• W2023463516 hasBestOaLocation W20234635161 @default.
• W2023463516 hasConcept C104317684 @default.
• W2023463516 hasConcept C116010114 @default.
• W2023463516 hasConcept C142724271 @default.
• W2023463516 hasConcept C153911025 @default.
• W2023463516 hasConcept C167625842 @default.
• W2023463516 hasConcept C177907266 @default.
• W2023463516 hasConcept C187882448 @default.
• W2023463516 hasConcept C189482833 @default.
• W2023463516 hasConcept C2779134260 @default.
• W2023463516 hasConcept C31705614 @default.
• W2023463516 hasConcept C502032728 @default.
• W2023463516 hasConcept C515207424 @default.
• W2023463516 hasConcept C52789158 @default.
• W2023463516 hasConcept C54355233 @default.
• W2023463516 hasConcept C71924100 @default.
• W2023463516 hasConcept C86803240 @default.
• W2023463516 hasConceptScore W2023463516C104317684 @default.
• W2023463516 hasConceptScore W2023463516C116010114 @default.
• W2023463516 hasConceptScore W2023463516C142724271 @default.
• W2023463516 hasConceptScore W2023463516C153911025 @default.
• W2023463516 hasConceptScore W2023463516C167625842 @default.
• W2023463516 hasConceptScore W2023463516C177907266 @default.

• next