Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023466083> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2023466083 endingPage "62" @default.
- W2023466083 startingPage "57" @default.
- W2023466083 abstract "In the present study, we have investigated the involvement of the cAMP signal transduction pathways in young and aged rats. A significantly higher endogenous adenosine 3':5'-cyclic monophosphate (cAMP) level and a significant decline of the adenylate cyclase [AC, ATP pyrophosphate-lyase (cyclizing), EC.4.6.1.1.] activity were observed in striatal tissue from young rats (3 months) in comparison to aged rats (approximately 40 months). In the nucleus accumbens (NA), no age-dependent changes in the cAMP concentration and in the AC basal activity were found. To address the question, whether the interactions of guanine nucleotide-binding protein (G-protein) subunits (G alpha s and Gi) with AC have changed in the aging process, various pharmacological agents that modulate the AC activity (e.g., beta, tau-imidoguanine 5'-triphosphate (GppNHp), sodium fluoride (NaF), forskolin (FSK), and the combinations of GppNHp plus FSK, NaF plus FSK, and NaF plus ethanol (ETOH)) were applied. In addition, a [3H]FSK binding test was carried out. In striatal and NA tissue, the stimulation of the AC activity by FSK was inhibited by GppNHp (via Gi-protein) and was superadditive by the combination of FSK and NaF (via Gs-protein). The absolute AC activity upon stimulation by all agents used was significantly lower in the aged striatum compared to young striatum. In the NA, however, the AC activity showed an age-dependent reduction only upon FSK and upon FSK plus GppNHp stimulation. There was no difference in the specific [3H]FSK binding to the G alpha s protein-coupled catalytic subunit of the AC between young and aged animals both in the striatum and NA.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2023466083 created "2016-06-24" @default.
- W2023466083 creator A5023427290 @default.
- W2023466083 creator A5063967677 @default.
- W2023466083 date "1993-07-01" @default.
- W2023466083 modified "2023-09-25" @default.
- W2023466083 title "Age-related alteration in signal transduction: involvement of the cAMP cascade" @default.
- W2023466083 cites W1576014737 @default.
- W2023466083 cites W1858552878 @default.
- W2023466083 cites W1876949150 @default.
- W2023466083 cites W1971642954 @default.
- W2023466083 cites W1974988661 @default.
- W2023466083 cites W1978199482 @default.
- W2023466083 cites W1979986714 @default.
- W2023466083 cites W1994851582 @default.
- W2023466083 cites W1997494772 @default.
- W2023466083 cites W2002804560 @default.
- W2023466083 cites W2010549805 @default.
- W2023466083 cites W2017968040 @default.
- W2023466083 cites W2018097015 @default.
- W2023466083 cites W2026375298 @default.
- W2023466083 cites W2031982165 @default.
- W2023466083 cites W2032769999 @default.
- W2023466083 cites W2042470597 @default.
- W2023466083 cites W2045534445 @default.
- W2023466083 cites W2049396064 @default.
- W2023466083 cites W2057939209 @default.
- W2023466083 cites W2066146438 @default.
- W2023466083 cites W2074788087 @default.
- W2023466083 cites W2077133289 @default.
- W2023466083 cites W2086222082 @default.
- W2023466083 cites W2140034850 @default.
- W2023466083 cites W4293247451 @default.
- W2023466083 doi "https://doi.org/10.1016/0006-8993(93)90428-p" @default.
- W2023466083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8402178" @default.
- W2023466083 hasPublicationYear "1993" @default.
- W2023466083 type Work @default.
- W2023466083 sameAs 2023466083 @default.
- W2023466083 citedByCount "31" @default.
- W2023466083 countsByYear W20234660832012 @default.
- W2023466083 countsByYear W20234660832013 @default.
- W2023466083 countsByYear W20234660832014 @default.
- W2023466083 countsByYear W20234660832017 @default.
- W2023466083 countsByYear W20234660832018 @default.
- W2023466083 countsByYear W20234660832021 @default.
- W2023466083 countsByYear W20234660832022 @default.
- W2023466083 countsByYear W20234660832023 @default.
- W2023466083 crossrefType "journal-article" @default.
- W2023466083 hasAuthorship W2023466083A5023427290 @default.
- W2023466083 hasAuthorship W2023466083A5063967677 @default.
- W2023466083 hasConcept C126322002 @default.
- W2023466083 hasConcept C134018914 @default.
- W2023466083 hasConcept C180526460 @default.
- W2023466083 hasConcept C181199279 @default.
- W2023466083 hasConcept C185592680 @default.
- W2023466083 hasConcept C24998067 @default.
- W2023466083 hasConcept C2776991684 @default.
- W2023466083 hasConcept C2779276759 @default.
- W2023466083 hasConcept C2780062018 @default.
- W2023466083 hasConcept C513476851 @default.
- W2023466083 hasConcept C55493867 @default.
- W2023466083 hasConcept C71924100 @default.
- W2023466083 hasConcept C86803240 @default.
- W2023466083 hasConceptScore W2023466083C126322002 @default.
- W2023466083 hasConceptScore W2023466083C134018914 @default.
- W2023466083 hasConceptScore W2023466083C180526460 @default.
- W2023466083 hasConceptScore W2023466083C181199279 @default.
- W2023466083 hasConceptScore W2023466083C185592680 @default.
- W2023466083 hasConceptScore W2023466083C24998067 @default.
- W2023466083 hasConceptScore W2023466083C2776991684 @default.
- W2023466083 hasConceptScore W2023466083C2779276759 @default.
- W2023466083 hasConceptScore W2023466083C2780062018 @default.
- W2023466083 hasConceptScore W2023466083C513476851 @default.
- W2023466083 hasConceptScore W2023466083C55493867 @default.
- W2023466083 hasConceptScore W2023466083C71924100 @default.
- W2023466083 hasConceptScore W2023466083C86803240 @default.
- W2023466083 hasIssue "1" @default.
- W2023466083 hasLocation W20234660831 @default.
- W2023466083 hasLocation W20234660832 @default.
- W2023466083 hasOpenAccess W2023466083 @default.
- W2023466083 hasPrimaryLocation W20234660831 @default.
- W2023466083 hasRelatedWork W2002661707 @default.
- W2023466083 hasRelatedWork W2006697433 @default.
- W2023466083 hasRelatedWork W2007885146 @default.
- W2023466083 hasRelatedWork W2014971876 @default.
- W2023466083 hasRelatedWork W2046164801 @default.
- W2023466083 hasRelatedWork W2056306087 @default.
- W2023466083 hasRelatedWork W2058991568 @default.
- W2023466083 hasRelatedWork W2065224155 @default.
- W2023466083 hasRelatedWork W2398181117 @default.
- W2023466083 hasRelatedWork W2398262967 @default.
- W2023466083 hasVolume "618" @default.
- W2023466083 isParatext "false" @default.
- W2023466083 isRetracted "false" @default.
- W2023466083 magId "2023466083" @default.
- W2023466083 workType "article" @default.