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• W2023471650 abstract "Abstract During neonatal development, tendons undergo a well‐orchestrated process whereby extensive structural and compositional changes occur in synchrony to produce a normal tissue. Conversely, during the repair response to injury, structural and compositional changes occur, but a mechanically inferior tendon is produced. As a result, developmental processes have been postulated as a potential paradigm through which improved adult tissue healing may occur. By examining injury at distinctly different stages of development, vital information can be obtained into the structure–function relationships in tendon. The mouse is an intriguing developmental model due to the availability of assays and genetically altered animals. However, it has not previously been used for mechanical analysis of healing tendon due to the small size and fragile nature of neonatal tendons. The objective of this study was to evaluate the differential healing response in tendon at two distinct stages of development through mechanical, compositional, and structural properties. To accomplish this, a new in vivo surgical model and mechanical analysis method for the neonatal mouse Achilles tendons were developed. We demonstrated that injury during early development has an accelerated healing response when compared to injury during late development. This accelerated healing model can be used in future mechanistic studies to elucidate the method for improved adult tendon healing. © 2011 Orthopaedic Research Society Published by Wiley Periodicals, Inc. J Orthop Res 30:448–456, 2012" @default.
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• W2023471650 date "2011-08-24" @default.
• W2023471650 modified "2023-10-10" @default.
• W2023471650 title "Recapitulation of the Achilles tendon mechanical properties during neonatal development: A Study of differential healing during two stages of development in a mouse model" @default.
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• W2023471650 doi "https://doi.org/10.1002/jor.21542" @default.
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