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- W2023472190 abstract "Summary We investigated PAX5 expression in childhood B‐lineage acute lymphoblastic leukaemia (ALL). Seven of 21 children with B‐lineage ALL had multiple PAX5 variants, while 14 children and healthy controls showed full‐length (FL) and one variant PAX5 . By Western blotting, healthy controls displayed Pax5‐FL, while one short Pax5, derived from the deletion of exon 8 (Pax5‐ΔE8) was produced in 90% of ALL samples, as well as in ALL cell lines. PAX5‐ Δ E8 lacked more than 50% of the transactivation domain, indicating that aberrant Pax5 production might lead to the arrest of B‐cell differentiation, contributing to the pathogenesis of B‐lineage ALL." @default.
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- W2023472190 date "2006-11-27" @default.
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- W2023472190 title "Expression and production of aberrant PAX5 with deletion of exon 8 in B-lineage acute lymphoblastic leukaemia of children" @default.
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- W2023472190 doi "https://doi.org/10.1111/j.1365-2141.2006.06425.x" @default.
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