Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023472253> ?p ?o ?g. }
- W2023472253 endingPage "1781" @default.
- W2023472253 startingPage "1773" @default.
- W2023472253 abstract "Notch signaling controls cellular differentiation and proliferation. Recent studies have shown that Notch signaling plays an important role in the carcinogenesis and progression of a growing number of malignant tumors. We investigated the effect of Notch1 activation on human hepatocellular carcinoma (HCC). In five human HCC cell lines, it was found that SMMC7721 had relatively high while HepG2 relatively low expression of Notch1 and the activity of Notch signaling. Notch1 activation by transfection of active intracellular region of Notch1 (ICN1) into HCC HepG2 cells enhanced cell growth and proliferation, including in vitro single cell colony formation, anchorage-independent proliferation, and in vivo tumorigenicity. Notch1 activation also promoted HepG2 cell cycle progression. Suppression of Notch1 activation by RNAi of Notch1 or by γ-secretase inhibitor (GSI) in HCC SMMC7721 cells decreased cell growth capability and blocked cell cycle progression. Moreover, it was found that suppression of Notch1 activation induced SMMC7721 cell apoptosis, as demonstrated by apoptosis assays. These findings indicate that Notch1 activation promotes human HCC cell growth and proliferation, which may contribute to the progression of this type of malignant carcinoma." @default.
- W2023472253 created "2016-06-24" @default.
- W2023472253 creator A5007825659 @default.
- W2023472253 creator A5016340006 @default.
- W2023472253 creator A5024937446 @default.
- W2023472253 creator A5031173584 @default.
- W2023472253 creator A5043875837 @default.
- W2023472253 creator A5043931952 @default.
- W2023472253 creator A5061224769 @default.
- W2023472253 creator A5079839167 @default.
- W2023472253 creator A5083447643 @default.
- W2023472253 creator A5089184288 @default.
- W2023472253 date "2012-08-24" @default.
- W2023472253 modified "2023-10-14" @default.
- W2023472253 title "Notch1 activation contributes to tumor cell growth and proliferation in human hepatocellular carcinoma HepG2 and SMMC7721 cells" @default.
- W2023472253 cites W1897096064 @default.
- W2023472253 cites W1982412998 @default.
- W2023472253 cites W1983014406 @default.
- W2023472253 cites W1983942535 @default.
- W2023472253 cites W1984295575 @default.
- W2023472253 cites W1989105929 @default.
- W2023472253 cites W1995004385 @default.
- W2023472253 cites W2000550532 @default.
- W2023472253 cites W2016704574 @default.
- W2023472253 cites W2018527149 @default.
- W2023472253 cites W2020467756 @default.
- W2023472253 cites W2030232704 @default.
- W2023472253 cites W2030887551 @default.
- W2023472253 cites W2045106437 @default.
- W2023472253 cites W2050311403 @default.
- W2023472253 cites W2057421005 @default.
- W2023472253 cites W2058609662 @default.
- W2023472253 cites W2060782406 @default.
- W2023472253 cites W2061738087 @default.
- W2023472253 cites W2072989134 @default.
- W2023472253 cites W2073618113 @default.
- W2023472253 cites W2078836547 @default.
- W2023472253 cites W2087006687 @default.
- W2023472253 cites W2092123619 @default.
- W2023472253 cites W2099068827 @default.
- W2023472253 cites W2099293048 @default.
- W2023472253 cites W2099705390 @default.
- W2023472253 cites W2103935212 @default.
- W2023472253 cites W2124323423 @default.
- W2023472253 cites W2125905587 @default.
- W2023472253 cites W2129124160 @default.
- W2023472253 cites W2141043764 @default.
- W2023472253 cites W2149226292 @default.
- W2023472253 cites W2151843493 @default.
- W2023472253 cites W2154861644 @default.
- W2023472253 cites W2164406730 @default.
- W2023472253 cites W2167582537 @default.
- W2023472253 cites W2245227892 @default.
- W2023472253 doi "https://doi.org/10.3892/ijo.2012.1606" @default.
- W2023472253 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22922832" @default.
- W2023472253 hasPublicationYear "2012" @default.
- W2023472253 type Work @default.
- W2023472253 sameAs 2023472253 @default.
- W2023472253 citedByCount "26" @default.
- W2023472253 countsByYear W20234722532013 @default.
- W2023472253 countsByYear W20234722532014 @default.
- W2023472253 countsByYear W20234722532015 @default.
- W2023472253 countsByYear W20234722532016 @default.
- W2023472253 countsByYear W20234722532018 @default.
- W2023472253 countsByYear W20234722532019 @default.
- W2023472253 countsByYear W20234722532020 @default.
- W2023472253 countsByYear W20234722532022 @default.
- W2023472253 crossrefType "journal-article" @default.
- W2023472253 hasAuthorship W2023472253A5007825659 @default.
- W2023472253 hasAuthorship W2023472253A5016340006 @default.
- W2023472253 hasAuthorship W2023472253A5024937446 @default.
- W2023472253 hasAuthorship W2023472253A5031173584 @default.
- W2023472253 hasAuthorship W2023472253A5043875837 @default.
- W2023472253 hasAuthorship W2023472253A5043931952 @default.
- W2023472253 hasAuthorship W2023472253A5061224769 @default.
- W2023472253 hasAuthorship W2023472253A5079839167 @default.
- W2023472253 hasAuthorship W2023472253A5083447643 @default.
- W2023472253 hasAuthorship W2023472253A5089184288 @default.
- W2023472253 hasBestOaLocation W20234722531 @default.
- W2023472253 hasConcept C121608353 @default.
- W2023472253 hasConcept C1491633281 @default.
- W2023472253 hasConcept C161879069 @default.
- W2023472253 hasConcept C190283241 @default.
- W2023472253 hasConcept C2779256057 @default.
- W2023472253 hasConcept C2781018059 @default.
- W2023472253 hasConcept C29537977 @default.
- W2023472253 hasConcept C502942594 @default.
- W2023472253 hasConcept C54355233 @default.
- W2023472253 hasConcept C55493867 @default.
- W2023472253 hasConcept C555283112 @default.
- W2023472253 hasConcept C62112901 @default.
- W2023472253 hasConcept C62478195 @default.
- W2023472253 hasConcept C86803240 @default.
- W2023472253 hasConcept C95444343 @default.
- W2023472253 hasConceptScore W2023472253C121608353 @default.
- W2023472253 hasConceptScore W2023472253C1491633281 @default.
- W2023472253 hasConceptScore W2023472253C161879069 @default.
- W2023472253 hasConceptScore W2023472253C190283241 @default.