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- W2023474034 abstract "The development of an optimized direct assay for carcinoembryonic antigen (CEA) in serum is described. CEA was purified from liver metastases from colorectal carcinomas, and avid anti-CEA antibodies (Ka 1.0-1.6x10(11) L/mol) were produced in rabbits. Radiolabelling of CEA was performed by the Iodo-Gen method. Experiments performed in order to characterize antigen-antibody specificity and to work out assay conditions are described. In the separation step of the assay, problems associated with non-specific binding of radioligand were virtually eliminated by using a new solid-phase second antibody, based on monodisperse polymer particles. The clinical performance of the assay is demonstrated by its high ability to detect relapses in patients with mammary carcinoma." @default.
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- W2023474034 date "1982-06-01" @default.
- W2023474034 modified "2023-10-11" @default.
- W2023474034 title "A direct assay for carcinoembryonic antigen in serum and its diagnostic value in metastatic breast cancer" @default.
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- W2023474034 doi "https://doi.org/10.1016/s0009-9120(82)90543-4" @default.
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