Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023474435> ?p ?o ?g. }
- W2023474435 abstract "Aging in humans is associated with parallel changes in cognition, motivation, and motoric performance. Based on the human aging literature, we hypothesized that this constellation of age-related changes is mediated by the medial prefrontal cortex and that it would be observed in aging mice. Toward this end, we performed detailed assessments of cognition, motivation, and motoric behavior in aging mice. We assessed behavioral and cognitive performance in C57Bl/6 mice aged 6, 18, and 24 months, and followed this with microarray analysis of tissue from the medial prefrontal cortex and analysis of serum cytokine levels. Multivariate modeling of these data suggested that the age-related changes in cognition, motivation, motor performance, and prefrontal immune gene expression were highly correlated. Peripheral cytokine levels were also correlated with these variables, but less strongly than measures of prefrontal immune gene upregulation. To determine whether the observed immune gene expression changes were due to prefrontal microglial cells, we isolated CD11b-positive cells from the prefrontal cortex and subject them to next-generation RNA sequencing. Many of the immune changes present in whole medial prefrontal cortex were enriched in this cell population. These data suggest that, as in humans, cognition, motivation, and motoric performance in the mouse change together with age and are strongly associated with CNS immune gene upregulation." @default.
- W2023474435 created "2016-06-24" @default.
- W2023474435 creator A5016341690 @default.
- W2023474435 creator A5016506380 @default.
- W2023474435 creator A5029042864 @default.
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- W2023474435 creator A5054738149 @default.
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- W2023474435 creator A5076736990 @default.
- W2023474435 date "2011-03-01" @default.
- W2023474435 modified "2023-10-18" @default.
- W2023474435 title "Parallel declines in cognition, motivation, and locomotion in aging mice: Association with immune gene upregulation in the medial prefrontal cortex" @default.
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