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• W2023474993 abstract "Significance Hypochlorite is a powerful oxidant that is generated within the body by activated innate immune cells. When hypochlorite is produced, the host organism sustains collateral damage, particularly to proteins, and the accumulation of damaged (misfolded) proteins is a hallmark of inflammatory processes (e.g., in Alzheimer’s disease, atherosclerosis, and arthritis). In the present study, we show that the chaperone activity of human α 2 -macroglobulin, a highly abundant secreted protein, is dramatically increased by hypochlorite-induced structural modifications. The data support the conclusion that α 2 -macroglobulin is a unique component of the innate immune system that is posttranslationally regulated by hypochlorite to facilitate the clearance of potentially pathogenic misfolded proteins." @default.
• W2023474993 created "2016-06-24" @default.
• W2023474993 creator A5017953270 @default.
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• W2023474993 creator A5050117500 @default.
• W2023474993 creator A5091898546 @default.
• W2023474993 date "2014-05-05" @default.
• W2023474993 modified "2023-10-13" @default.
• W2023474993 title "Hypochlorite-induced structural modifications enhance the chaperone activity of human α ₂ -macroglobulin" @default.
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• W2023474993 doi "https://doi.org/10.1073/pnas.1403379111" @default.
• W2023474993 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4034205" @default.
• W2023474993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24799681" @default.
• W2023474993 hasPublicationYear "2014" @default.
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