FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023475055> ?p ?o ?g. }

• W2023475055 endingPage "12" @default.
• W2023475055 startingPage "1" @default.
• W2023475055 abstract "• Immunomodulatory activity of water-soluble polyanionic macromolecules from Codium fragile investigated. • The fraction F 2 stimulated RAW264.7 cells through the activation of NF-κB and MAPK pathway. • The backbone was linked by β-(1→3)- d -mannopyranosides. • The sulfate groups were found mostly on mannosyl residues at O -4 position. • Protein moiety was the essential part of fraction F 2 for the strong activation of RAW264.7 cells. Water-soluble anionic macromolecules isolated from Codium fragile and fractionated using ion-exchange chromatography were investigated to determine their molecular characteristics and immunostimulating activity. The crude molecules and fractions (F 1 , F 2 , and F 3 ) consisted mostly of carbohydrates (44.1–80.5%), sulfates (3.2–22.2%) and proteins (3.0–15.7%) with small amounts of uronic acids (1.1–4.2%), and included different levels of mannose (91.3–18.7%), glucose (62.7–8.6%) and galactose (37.5–59.5%). These molecules contained one or two subfractions with molecular weights ( M w ) ranging from 148 × 10 3 to 4879 × 10 3 g/mol. The crude, F 1 and F 2 stimulated RAW264.7 cells to produce considerable amounts of pro-inflammatory mediator nitric oxide (NO) and cytokines. The treatment of sample molecules facilitated the degradation of Iκ-B and phosphorylation of MAPK in RAW264.7 cells, suggesting that they might stimulate RAW264.7 cells through the activation of NF-κB and MAPK pathway. Proteins in fraction F 2 were essential to possess its bioactivity and its main backbone was composed of mixed linkages of (1→3)-α and β- d -mannan." @default.
• W2023475055 created "2016-06-24" @default.
• W2023475055 creator A5021043061 @default.
• W2023475055 creator A5021355234 @default.
• W2023475055 creator A5035269096 @default.
• W2023475055 creator A5039154387 @default.
• W2023475055 creator A5091049135 @default.
• W2023475055 date "2013-08-01" @default.
• W2023475055 modified "2023-10-13" @default.
• W2023475055 title "Molecular characteristics and biological activities of anionic macromolecules from Codium fragile" @default.
• W2023475055 cites W1545121368 @default.
• W2023475055 cites W1775749144 @default.
• W2023475055 cites W1968834637 @default.
• W2023475055 cites W1971065904 @default.
• W2023475055 cites W1975287835 @default.
• W2023475055 cites W1978505945 @default.
• W2023475055 cites W1982323023 @default.
• W2023475055 cites W1986574293 @default.
• W2023475055 cites W1986888747 @default.
• W2023475055 cites W1989979448 @default.
• W2023475055 cites W1990802251 @default.
• W2023475055 cites W1991444547 @default.
• W2023475055 cites W1991944541 @default.
• W2023475055 cites W1992670830 @default.
• W2023475055 cites W1995356642 @default.
• W2023475055 cites W1998645387 @default.
• W2023475055 cites W2004187431 @default.
• W2023475055 cites W2010001103 @default.
• W2023475055 cites W2010743254 @default.
• W2023475055 cites W2011169355 @default.
• W2023475055 cites W2019834536 @default.
• W2023475055 cites W2021203184 @default.
• W2023475055 cites W2022603507 @default.
• W2023475055 cites W2029180929 @default.
• W2023475055 cites W2039471616 @default.
• W2023475055 cites W2044335811 @default.
• W2023475055 cites W2050234460 @default.
• W2023475055 cites W2052731445 @default.
• W2023475055 cites W2057007315 @default.
• W2023475055 cites W2071847782 @default.
• W2023475055 cites W2075168072 @default.
• W2023475055 cites W2076865326 @default.
• W2023475055 cites W2078032276 @default.
• W2023475055 cites W2122296266 @default.
• W2023475055 cites W2135989733 @default.
• W2023475055 cites W2143786633 @default.
• W2023475055 cites W2147296897 @default.
• W2023475055 cites W2154721196 @default.
• W2023475055 cites W2156258819 @default.
• W2023475055 cites W2159811950 @default.
• W2023475055 cites W2162147900 @default.
• W2023475055 cites W2169259994 @default.
• W2023475055 doi "https://doi.org/10.1016/j.ijbiomac.2013.04.022" @default.
• W2023475055 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23597705" @default.
• W2023475055 hasPublicationYear "2013" @default.
• W2023475055 type Work @default.
• W2023475055 sameAs 2023475055 @default.
• W2023475055 citedByCount "52" @default.
• W2023475055 countsByYear W20234750552014 @default.
• W2023475055 countsByYear W20234750552015 @default.
• W2023475055 countsByYear W20234750552016 @default.
• W2023475055 countsByYear W20234750552017 @default.
• W2023475055 countsByYear W20234750552018 @default.
• W2023475055 countsByYear W20234750552019 @default.
• W2023475055 countsByYear W20234750552020 @default.
• W2023475055 countsByYear W20234750552021 @default.
• W2023475055 countsByYear W20234750552022 @default.
• W2023475055 countsByYear W20234750552023 @default.
• W2023475055 crossrefType "journal-article" @default.
• W2023475055 hasAuthorship W2023475055A5021043061 @default.
• W2023475055 hasAuthorship W2023475055A5021355234 @default.
• W2023475055 hasAuthorship W2023475055A5035269096 @default.
• W2023475055 hasAuthorship W2023475055A5039154387 @default.
• W2023475055 hasAuthorship W2023475055A5091049135 @default.
• W2023475055 hasConcept C100817775 @default.
• W2023475055 hasConcept C11960822 @default.
• W2023475055 hasConcept C163994747 @default.
• W2023475055 hasConcept C181199279 @default.
• W2023475055 hasConcept C185592680 @default.
• W2023475055 hasConcept C204389451 @default.
• W2023475055 hasConcept C2775887612 @default.
• W2023475055 hasConcept C2778173381 @default.
• W2023475055 hasConcept C2778284416 @default.
• W2023475055 hasConcept C55493867 @default.
• W2023475055 hasConcept C57074206 @default.
• W2023475055 hasConcept C58121356 @default.
• W2023475055 hasConceptScore W2023475055C100817775 @default.
• W2023475055 hasConceptScore W2023475055C11960822 @default.
• W2023475055 hasConceptScore W2023475055C163994747 @default.
• W2023475055 hasConceptScore W2023475055C181199279 @default.
• W2023475055 hasConceptScore W2023475055C185592680 @default.
• W2023475055 hasConceptScore W2023475055C204389451 @default.
• W2023475055 hasConceptScore W2023475055C2775887612 @default.
• W2023475055 hasConceptScore W2023475055C2778173381 @default.
• W2023475055 hasConceptScore W2023475055C2778284416 @default.
• W2023475055 hasConceptScore W2023475055C55493867 @default.
• W2023475055 hasConceptScore W2023475055C57074206 @default.
• W2023475055 hasConceptScore W2023475055C58121356 @default.

• next