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- W2023477387 endingPage "455" @default.
- W2023477387 startingPage "438" @default.
- W2023477387 abstract "A number of studies have assessed a relationship between the T102C polymorphism in the HTR2A gene with an increased risk of major depressive disorder (MDD), bipolar disorder (BPD), and schizophrenia (SCZ). However, the results have been inconsistent. Hence, we performed this study to further evaluate potential associations between the T102C polymorphism and MDD, BPD, and SCZ. The strength of separate associations between the T102C polymorphism and the risk of MDD, BPD, or SCZ was measured by ORs and 95% confidence intervals (CIs) in six genetic models. Cochran's chi-square-based Q-statistic and I(2) were used to evaluate the heterogeneity between studies. The funnel plot and the Egger's test were used to assess the publication bias. Cumulative meta-analysis was also performed to evaluate the trend in OR over time. No significant association was found in the overall analysis of MDD, BPD and SCZ with a sample size of 17,178 cases and 20,855 control subjects. In a further analysis by ethnicity, the OR and 95% CIs indicated the T102C polymorphism was not associated with MDD, BPD, or SCZ in Caucasian, Asian or Chinese populations. No publication bias was observed in the meta-analysis, and the cumulative analyses indicated the robust stability of the results. Thus, the results of our study indicate that the T102C polymorphism is not associates with increased susceptibility to MDD, BPD, and SCZ." @default.
- W2023477387 created "2016-06-24" @default.
- W2023477387 creator A5011877960 @default.
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- W2023477387 creator A5071634770 @default.
- W2023477387 creator A5089890518 @default.
- W2023477387 creator A5091158220 @default.
- W2023477387 date "2014-06-24" @default.
- W2023477387 modified "2023-10-07" @default.
- W2023477387 title "Association of the T102C polymorphism in the<i>HTR2A</i>gene with major depressive disorder, bipolar disorder, and schizophrenia" @default.
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