FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023477614> ?p ?o ?g. }

• W2023477614 endingPage "131" @default.
• W2023477614 startingPage "127" @default.
• W2023477614 abstract "Grapefruit juice increases the bioavailability of several drugs known to be metabolized by CYP3A enzymes. Ketoconazole and itraconazole can increase the area under the concentration-time curve [AUC(0-infinity)] of triazolam, a substrate of CYP3A, by more than twenty times.In this randomized crossover study the effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of triazolam was investigated. Ten healthy young subjects received a single 0.25 mg dose of triazolam with either 250 ml grapefruit juice or water. Plasma concentrations and effects of triazolam were measured up to 17 hours.Grapefruit juice increased the AUC(0-infinity) of triazolam in each subject and the peak concentration in nine of the 10 subjects. The mean AUC(0-infinity) of triazolam was increased 1.5-fold (p < 0.001) and the peak concentration was increased 1.3-fold (p < 0.05) by grapefruit juice. Grapefruit juice postponed the peak time of triazolam from 1.6 hours to 2.5 hours (p < 0.05). Grapefruit juice increased the effects of triazolam slightly; drowsiness was significantly (p < 0.05) enhanced.Grapefruit juice can increase the plasma concentrations and effects of oral triazolam." @default.
• W2023477614 created "2016-06-24" @default.
• W2023477614 creator A5009770695 @default.
• W2023477614 creator A5052949887 @default.
• W2023477614 creator A5089475081 @default.
• W2023477614 creator A5091721438 @default.
• W2023477614 date "1995-08-01" @default.
• W2023477614 modified "2023-10-12" @default.
• W2023477614 title "Plasma concentrations of triazolam are increased by concomitant ingestion of grapefruit juice" @default.
• W2023477614 cites W1536161802 @default.
• W2023477614 cites W1575637830 @default.
• W2023477614 cites W1971684396 @default.
• W2023477614 cites W1972432056 @default.
• W2023477614 cites W1974175694 @default.
• W2023477614 cites W1999715469 @default.
• W2023477614 cites W2004576165 @default.
• W2023477614 cites W2021595332 @default.
• W2023477614 cites W2024587809 @default.
• W2023477614 cites W2035019909 @default.
• W2023477614 cites W2042033252 @default.
• W2023477614 cites W2048106894 @default.
• W2023477614 cites W2051508505 @default.
• W2023477614 cites W2079752760 @default.
• W2023477614 doi "https://doi.org/10.1016/0009-9236(95)90188-4" @default.
• W2023477614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7648762" @default.
• W2023477614 hasPublicationYear "1995" @default.
• W2023477614 type Work @default.
• W2023477614 sameAs 2023477614 @default.
• W2023477614 citedByCount "129" @default.
• W2023477614 countsByYear W20234776142012 @default.
• W2023477614 countsByYear W20234776142013 @default.
• W2023477614 countsByYear W20234776142014 @default.
• W2023477614 countsByYear W20234776142015 @default.
• W2023477614 countsByYear W20234776142016 @default.
• W2023477614 countsByYear W20234776142017 @default.
• W2023477614 countsByYear W20234776142018 @default.
• W2023477614 countsByYear W20234776142019 @default.
• W2023477614 countsByYear W20234776142020 @default.
• W2023477614 countsByYear W20234776142021 @default.
• W2023477614 countsByYear W20234776142022 @default.
• W2023477614 countsByYear W20234776142023 @default.
• W2023477614 crossrefType "journal-article" @default.
• W2023477614 hasAuthorship W2023477614A5009770695 @default.
• W2023477614 hasAuthorship W2023477614A5052949887 @default.
• W2023477614 hasAuthorship W2023477614A5089475081 @default.
• W2023477614 hasAuthorship W2023477614A5091721438 @default.
• W2023477614 hasConcept C112705442 @default.
• W2023477614 hasConcept C142724271 @default.
• W2023477614 hasConcept C170493617 @default.
• W2023477614 hasConcept C181389837 @default.
• W2023477614 hasConcept C185592680 @default.
• W2023477614 hasConcept C193230392 @default.
• W2023477614 hasConcept C204787440 @default.
• W2023477614 hasConcept C27081682 @default.
• W2023477614 hasConcept C2776773239 @default.
• W2023477614 hasConcept C2778173252 @default.
• W2023477614 hasConcept C2779738154 @default.
• W2023477614 hasConcept C2781353486 @default.
• W2023477614 hasConcept C3018190196 @default.
• W2023477614 hasConcept C31903555 @default.
• W2023477614 hasConcept C55493867 @default.
• W2023477614 hasConcept C59822182 @default.
• W2023477614 hasConcept C71924100 @default.
• W2023477614 hasConcept C86803240 @default.
• W2023477614 hasConcept C87813604 @default.
• W2023477614 hasConcept C98274493 @default.
• W2023477614 hasConceptScore W2023477614C112705442 @default.
• W2023477614 hasConceptScore W2023477614C142724271 @default.
• W2023477614 hasConceptScore W2023477614C170493617 @default.
• W2023477614 hasConceptScore W2023477614C181389837 @default.
• W2023477614 hasConceptScore W2023477614C185592680 @default.
• W2023477614 hasConceptScore W2023477614C193230392 @default.
• W2023477614 hasConceptScore W2023477614C204787440 @default.
• W2023477614 hasConceptScore W2023477614C27081682 @default.
• W2023477614 hasConceptScore W2023477614C2776773239 @default.
• W2023477614 hasConceptScore W2023477614C2778173252 @default.
• W2023477614 hasConceptScore W2023477614C2779738154 @default.
• W2023477614 hasConceptScore W2023477614C2781353486 @default.
• W2023477614 hasConceptScore W2023477614C3018190196 @default.
• W2023477614 hasConceptScore W2023477614C31903555 @default.
• W2023477614 hasConceptScore W2023477614C55493867 @default.
• W2023477614 hasConceptScore W2023477614C59822182 @default.
• W2023477614 hasConceptScore W2023477614C71924100 @default.
• W2023477614 hasConceptScore W2023477614C86803240 @default.
• W2023477614 hasConceptScore W2023477614C87813604 @default.
• W2023477614 hasConceptScore W2023477614C98274493 @default.
• W2023477614 hasIssue "2" @default.
• W2023477614 hasLocation W20234776141 @default.
• W2023477614 hasLocation W20234776142 @default.
• W2023477614 hasOpenAccess W2023477614 @default.
• W2023477614 hasPrimaryLocation W20234776141 @default.
• W2023477614 hasRelatedWork W2000595322 @default.
• W2023477614 hasRelatedWork W2023477614 @default.
• W2023477614 hasRelatedWork W2067195248 @default.
• W2023477614 hasRelatedWork W2095491647 @default.
• W2023477614 hasRelatedWork W2253613220 @default.
• W2023477614 hasRelatedWork W2416052550 @default.
• W2023477614 hasRelatedWork W2431162471 @default.

• next