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• W2023481807 endingPage "2002" @default.
• W2023481807 startingPage "1993" @default.
• W2023481807 abstract "Background: Berbamine, a natural compound from Barberry, was reported to protect myocardium from ischemia/reperfusion (I/R) injury, but the underlying mechanisms are largely unknown. Methods and Results: Berbamine pretreatment from 10 to 100nmol/L concentration-dependently improved post-ischemic myocardial function. Similar protection was confirmed in isolated cardiomyocytes characterized by the attenuation of I/R-induced intracellular free Ca2+ concentration ([Ca2+]i) overloading and the depression of cell shortening and Ca2+ transients, which were partially mimicked but not augmented by calpain inhibitor calpeptin and abolished by mitochondrial ATP-sensitive potassium (mitoKATP) channel inhibitor 5-hydroxydecanoate (5-HD) and phosphoinositide 3-kinase (PI3K) inhibitor wortmannin. Consistently, I/R-induced increase of calpain activity and decrease of sarcoplasmic reticulum Ca2+ ATPase (SERCA2) activity; and protein expression of SERCA2a, desmin, calpastatin and Akt was significantly attenuated by berbamine. In addition, I/R-decreased Akt protein was reversed by calpeptin. Moreover, berbamine further increased I/R-enhanced phosphorylation of Akt and glycogen synthase kinase-3β (GSK3β). These protections were abolished by wortmannin. Furthermore, berbamine significantly attenuated I/R-induced lactate dehydrogenase release, infarct size and contractile dysfunction, and such cardioprotective actions were abolished by wortmannin and 5-HD or mimicked by glycogen synthase kinase-3β (GSK3β) inhibitor SB216763 but without additive effect. Conclusions: These findings suggest that berbamine confers cardioprotection against I/R injury by attenuating [Ca2+]i overloading and preventing calpain activation through the activation of the PI3K-Akt-GSK3β pathway and, subsequently, opening of the mitoKATP channel. (Circ J 2012; 76: 1993–2002)" @default.
• W2023481807 created "2016-06-24" @default.
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• W2023481807 date "2012-01-01" @default.
• W2023481807 modified "2023-09-24" @default.
• W2023481807 title "Berbamine Protects the Heart From Ischemia/Reperfusion Injury by Maintaining Cytosolic Ca²⁺ Homeostasis and Preventing Calpain Activation" @default.
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• W2023481807 doi "https://doi.org/10.1253/circj.cj-11-1431" @default.
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