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• W2023482207 abstract "Disorganization of collagen fibers is a sign of early-stage cartilage degeneration in osteoarthritic knees. Water molecules trapped within well-organized collagen fibrils would be sensitive to collagen alterations. Multicomponent effective transverse relaxation (T2*) mapping with ultrashort echo time acquisitions is here proposed to probe short T(2) relaxations in those trapped water molecules. Six human tibial plateau explants were scanned on a 3T MRI scanner using a home-developed ultrashort echo time sequence with echo times optimized via Monte Carlo simulations. Time constants and component intensities of T2* decays were calculated at individual pixels, using the nonnegative least squares algorithm. Four T2*-decay types were found: 99% of cartilage pixels having mono-, bi-, or nonexponential decay, and 1% showing triexponential decay. Short T2* was mainly in 1-6 ms, while long T2* was ∼ 22 ms. A map of decay types presented spatial distribution of these T2* decays. These results showed the technical feasibility of multicomponent T2* mapping on human knee cartilage explants." @default.
• W2023482207 created "2016-06-24" @default.
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• W2023482207 date "2010-09-23" @default.
• W2023482207 modified "2023-10-16" @default.
• W2023482207 title "Multicomponent <i>T</i>₂* mapping of knee cartilage: Technical feasibility ex vivo" @default.
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• W2023482207 doi "https://doi.org/10.1002/mrm.22450" @default.
• W2023482207 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2965791" @default.
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