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• W2023483032 abstract "To investigate the anti-inflammatory and hemodynamic effects of 17beta-estradiol in men undergoing elective coronary artery bypass graft surgery (CABG).Prospective, randomized, controlled.Operating room and intensive care unit in a university hospital.Twenty-one men undergoing primary, elective CABG surgery.17beta-estradiol, 2mg, was given orally twice in 14 hours before the operation.Leukocyte counts, plasma myeloperoxidase, tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, and IL-10 were measured perioperatively. Leukocyte counts were lower in the 17beta-estradiol group than in controls at 6 hours (11.4 +/- 2.0 hours v 15.5 +/- 4.7 hours x 10(9)/L) and 20 hours (11.6 +/- 1.9 hours v 13.6 +/- 2.5 hours x 10(9)/L) after reperfusion (p = 0.03). The release of myeloperoxidase was lower in the 17beta-estradiol group than in controls (5 minutes; 634.4 +/- 213.1 microg/mL v 773.1 +/- 209.3 microg/mL; 4 hours, 305.0 +/- 108.0 microg/mL v 441.3 +/- 191.6 microg/mL; p = 0.02). Systemic vascular resistance index was lower just after cardiopulmonary bypass, and cardiac index was higher postoperatively in the 17beta-estradiol group as compared with controls.Pretreatment with 17beta-estradiol can limit leukocyte activation in men after CABG surgery." @default.
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• W2023483032 date "2001-08-01" @default.
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• W2023483032 title "Anti-inflammatory effects of 17β-estradiol pretreatment in men after coronary artery surgery" @default.
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• W2023483032 doi "https://doi.org/10.1053/jcan.2001.24981" @default.
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