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- W2023483577 abstract "Here we present the solution phase parallel synthesis of a combinatorial library consisting of 776 new substituted 3-phenylsulfonyl-[1,2,3]triazolo[1,5-a]quinazolines and a study of the relation of their structure with a 5-HT(6) receptor antagonistic activity in a functional cell (HEK 293) analysis and radioligand competitive binding. We have found highly active and selective 5-HT(6)R antagonists. The most active 5-HT(6)R antagonists have IC(50) <100 nM in a functional assay, and K(i) <10 nM in a binding assay, which is 100 times higher than the activity with respect to other serotonin receptors." @default.
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- W2023483577 date "2010-03-29" @default.
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- W2023483577 title "Solution Phase Parallel Synthesis of Substituted 3-Phenylsulfonyl-[1,2,3]triazolo[1,5-<i>a</i>]quinazolines: Selective Serotonin 5-HT<sub>6</sub> Receptor Antagonists" @default.
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- W2023483577 doi "https://doi.org/10.1021/cc1000049" @default.
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