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- W2023484372 abstract "ABSTRACT We report that type I interferons (IFNs) upregulate latent membrane protein 1 (LMP-1) expression by direct activation of the ED-L1 promoter in several Epstein-Barr virus (EBV)-carrying Burkitt's lymphoma lines. In EBV-infected primary B cells, IFN-α transiently upregulates LMP-1 mRNA, but not protein levels, followed by downregulation of both, suggesting a novel antiproliferative mechanism of type I IFNs. Furthermore, our results may explain the expression of LMP-1 in memory B cells of systemic lupus erythematosus patients." @default.
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- W2023484372 date "2012-04-15" @default.
- W2023484372 modified "2023-10-03" @default.
- W2023484372 title "Latency Type-Dependent Modulation of Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Expression by Type I Interferons in B Cells" @default.
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- W2023484372 doi "https://doi.org/10.1128/jvi.06829-11" @default.
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