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- W2023484412 abstract "Polymer-supported O6-(benzotriazol-1-yl)inosine derivatives (Pol-I and Pol-dI) have been synthesized reasonably effectively via reaction of nucleoside phosphonium salts with polymer-linked HOBt (Pol-HOBt). In constast to solution chemistry, use of polymer-supported BOP (Pol-BOP) did not lead to efficient nucleoside loading. Presence of the nucleosides on the support could be readily detected by MAS NMR. Exposure of the polymer-supported nucleosides, Pol-I and Pol-dI, to alcohol, phenol, thiol and amine nucleophiles caused cleavage from the support leading directly to the C-6 modified nucleoside analogues. To our knowledge, these are the first examples of the application of such technology for nucleoside modification. Where possible, results of reactions with the polymer-supported nucleosides are compared to those from solution chemistry, providing insight into the differences between the two techniques. These new polymer-supported nucleosides can be conveniently utilized for diversity-oriented synthesis." @default.
- W2023484412 created "2016-06-24" @default.
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- W2023484412 date "2008-04-23" @default.
- W2023484412 modified "2023-10-07" @default.
- W2023484412 title "A Novel Polymer Supported Approach to Nucleoside Modification" @default.
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- W2023484412 doi "https://doi.org/10.1021/jo702558n" @default.
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