FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023484466> ?p ?o ?g. }

• W2023484466 endingPage "93" @default.
• W2023484466 startingPage "75" @default.
• W2023484466 abstract "The differentiation of the predominant cell types of the mucosal epithelium of the mammalian gastrointestinal tract is characterized by increasing amonts of an intermediate-sized filament (IF) protein designated cytokeratin (CK) 20 which is a major cellular protein of mature enterocytes and goblet cells. Here we report the isolation of the human gene encoding CK 20, its complete nucleotide sequence and the amino acid sequence deduced therefrom that identifies this polypeptide (mol. wt. 48553) as a member of the type I-CK subfamily. Remarkable, however, is the comparably great sequence divergence of CK 20 from all other known type I-CKs, with only 58% identical amino acids in the conserved α-helical ‘rod’ domain of CK 20 and, e.g. CK 14. Using riboprobes corresponding to exon 6 of the gene in Northern blot and ribonuclease protection assays, we show that the ∼1.75 kb mRNA encoding CK 20 is specifically produced in cells of the intestinal and gastric mucosa, including tumors and cell lines derived therefrom. The appearance of CK 20-positive cells in human embryonic and fetal development and in adult tissues has been studied using immunohistochemistry with CK 20-specific antibodies. CK 20 synthesis has first been recognized at embryonic week 8 in individual ‘converted’ simple epithelial cells of the developing intestinal mucosa. In later fetal stages, CK 20 synthesis extends over most goblet cells and a variable number of villus enterocytes. The distribution of CK 20-positive cells in the developing gastric and intestinal mucosa is similar to—but not identical with—the pattern in the adult intestine in which all enterocytes and goblet cells as well as certain ‘low-differentiated’ columnar cells contain CK 20, whereas the neuroendocrine (‘enterochromaffin’) and Paneth cells are negative. In gastrointestinal carcinomas similarly examined, CK 20 has been detected in almost all cases (50/52) of colorectal adenocarcinomas, including all grades of differentiation and malignancy and also metastatic tumors, whereas CK 20 immunostaining in gastric carcinomas has been found less consistent and more heterogeneous. The possible biological meaning of the specific expression of the CK 20 gene in certain cells of the gastrointestinal tract and carcinomas derived therefrom and the regulatory mechanisms involved in the integration of the protein in the IF cytoskeleton are discussed." @default.
• W2023484466 created "2016-06-24" @default.
• W2023484466 creator A5022520700 @default.
• W2023484466 creator A5023020921 @default.
• W2023484466 creator A5036253009 @default.
• W2023484466 creator A5037029369 @default.
• W2023484466 creator A5052267229 @default.
• W2023484466 creator A5064788187 @default.
• W2023484466 creator A5081157275 @default.
• W2023484466 creator A5086202167 @default.
• W2023484466 date "1993-06-01" @default.
• W2023484466 modified "2023-10-11" @default.
• W2023484466 title "The human gene encoding cytokeratin 20 and its expression during fetal development and in gastrointestinal carcinomas" @default.
• W2023484466 cites W1479725497 @default.
• W2023484466 cites W1490523864 @default.
• W2023484466 cites W1498629420 @default.
• W2023484466 cites W1514019531 @default.
• W2023484466 cites W15327343 @default.
• W2023484466 cites W1594237786 @default.
• W2023484466 cites W1776015964 @default.
• W2023484466 cites W1857616382 @default.
• W2023484466 cites W1961173286 @default.
• W2023484466 cites W1963675686 @default.
• W2023484466 cites W1970761470 @default.
• W2023484466 cites W1971575115 @default.
• W2023484466 cites W1980793586 @default.
• W2023484466 cites W1984502321 @default.
• W2023484466 cites W1992470401 @default.
• W2023484466 cites W1992534140 @default.
• W2023484466 cites W1993418874 @default.
• W2023484466 cites W1995073035 @default.
• W2023484466 cites W1997469925 @default.
• W2023484466 cites W2001258296 @default.
• W2023484466 cites W2002177245 @default.
• W2023484466 cites W2003356317 @default.
• W2023484466 cites W2003954517 @default.
• W2023484466 cites W2004109496 @default.
• W2023484466 cites W2005835292 @default.
• W2023484466 cites W2008398178 @default.
• W2023484466 cites W2014669590 @default.
• W2023484466 cites W2016693266 @default.
• W2023484466 cites W2023114874 @default.
• W2023484466 cites W2023623142 @default.
• W2023484466 cites W2023913286 @default.
• W2023484466 cites W2027191569 @default.
• W2023484466 cites W2035776517 @default.
• W2023484466 cites W2042333171 @default.
• W2023484466 cites W2044453539 @default.
• W2023484466 cites W2048830694 @default.
• W2023484466 cites W2053713198 @default.
• W2023484466 cites W2057931621 @default.
• W2023484466 cites W2060937867 @default.
• W2023484466 cites W2066390328 @default.
• W2023484466 cites W2069860300 @default.
• W2023484466 cites W2072845062 @default.
• W2023484466 cites W2074465214 @default.
• W2023484466 cites W2076858319 @default.
• W2023484466 cites W2078119356 @default.
• W2023484466 cites W2081743971 @default.
• W2023484466 cites W2085406129 @default.
• W2023484466 cites W2091623476 @default.
• W2023484466 cites W2096548759 @default.
• W2023484466 cites W2106448082 @default.
• W2023484466 cites W2107611154 @default.
• W2023484466 cites W2110121884 @default.
• W2023484466 cites W2121168448 @default.
• W2023484466 cites W2123196611 @default.
• W2023484466 cites W2126332265 @default.
• W2023484466 cites W2133074709 @default.
• W2023484466 cites W2139838398 @default.
• W2023484466 cites W2143464311 @default.
• W2023484466 cites W2152885380 @default.
• W2023484466 cites W2153816320 @default.
• W2023484466 cites W2155995610 @default.
• W2023484466 cites W2164014955 @default.
• W2023484466 cites W2167097542 @default.
• W2023484466 cites W2169856028 @default.
• W2023484466 cites W2267138050 @default.
• W2023484466 cites W2418038645 @default.
• W2023484466 doi "https://doi.org/10.1111/j.1432-0436.1993.tb00648.x" @default.
• W2023484466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8359595" @default.
• W2023484466 hasPublicationYear "1993" @default.
• W2023484466 type Work @default.
• W2023484466 sameAs 2023484466 @default.
• W2023484466 citedByCount "190" @default.
• W2023484466 countsByYear W20234844662012 @default.
• W2023484466 countsByYear W20234844662013 @default.
• W2023484466 countsByYear W20234844662014 @default.
• W2023484466 countsByYear W20234844662015 @default.
• W2023484466 countsByYear W20234844662016 @default.
• W2023484466 countsByYear W20234844662017 @default.
• W2023484466 countsByYear W20234844662018 @default.
• W2023484466 countsByYear W20234844662019 @default.
• W2023484466 countsByYear W20234844662020 @default.
• W2023484466 countsByYear W20234844662021 @default.
• W2023484466 countsByYear W20234844662022 @default.
• W2023484466 countsByYear W20234844662023 @default.
• W2023484466 crossrefType "journal-article" @default.

• next