Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023486296> ?p ?o ?g. }
- W2023486296 endingPage "195" @default.
- W2023486296 startingPage "186" @default.
- W2023486296 abstract "Rosiglitazone (RGL) has been used to ameliorate lipids homeostasis and also to treat inflammatory diseases. However, RGL may reduce renal blood flow and glomerular filtration rate (GFR) predisposing to acute kidney injury (AKI). We investigated whether the treatment with RGL induces AKI in normocholesterolemic (NC) and hypercholesterolemic (HC) rats.We measured GFR by inulin clearance technique and we quantified urinary neutrophil gelatinase-associated lipocalin (uNGAL) in all groups at baseline and during Ang II-stimulated vasoconstriction. Moreover, we evaluated the presence of renal damaged by histologic examination.At baseline, NC and HC had normal and similar GFR. RGL treatment reduced GFR only in NC+RGL. Unexpectedly, HC+RGL showed high levels of uNGAL although GFR was at normal range. During Ang II-stimulated vasoconstriction, all groups showed reduction in GFR to the same range and we found high levels of uNGAL and high score of renal damage in HC and HC+RGL.RGL acts distinctly in normocholesterolemia and in hypercholesterolemia. Reduction in GFR provoked by RGL treatment did not allow the diagnosis of AKI in NC even in the presence of ANG II-stimulated vasoconstriction. However, AKI was diagnosed in HC+RGL at baseline although GFR was within normal range." @default.
- W2023486296 created "2016-06-24" @default.
- W2023486296 creator A5016295551 @default.
- W2023486296 creator A5025544794 @default.
- W2023486296 creator A5065631574 @default.
- W2023486296 date "2013-01-01" @default.
- W2023486296 modified "2023-09-23" @default.
- W2023486296 title "Rosiglitazone Did Not Induce Acute Kidney Injury in Normocholesterolemic Rats Despite Reduction in Glomerular Filtration Rate" @default.
- W2023486296 cites W1968018300 @default.
- W2023486296 cites W1972136146 @default.
- W2023486296 cites W1973436528 @default.
- W2023486296 cites W1974182036 @default.
- W2023486296 cites W1977964839 @default.
- W2023486296 cites W1990548208 @default.
- W2023486296 cites W1996544989 @default.
- W2023486296 cites W1996607461 @default.
- W2023486296 cites W1999654312 @default.
- W2023486296 cites W2002119286 @default.
- W2023486296 cites W2008938076 @default.
- W2023486296 cites W2023166018 @default.
- W2023486296 cites W2038046469 @default.
- W2023486296 cites W2057313488 @default.
- W2023486296 cites W2082432305 @default.
- W2023486296 cites W2085780424 @default.
- W2023486296 cites W2102606565 @default.
- W2023486296 cites W2105719905 @default.
- W2023486296 cites W2112565592 @default.
- W2023486296 cites W2114386003 @default.
- W2023486296 cites W2120822075 @default.
- W2023486296 cites W2121714067 @default.
- W2023486296 cites W2128712342 @default.
- W2023486296 cites W2137782744 @default.
- W2023486296 cites W2139074604 @default.
- W2023486296 cites W2141793342 @default.
- W2023486296 cites W2147641203 @default.
- W2023486296 cites W2149590342 @default.
- W2023486296 cites W2169588409 @default.
- W2023486296 cites W2319066204 @default.
- W2023486296 cites W2410004751 @default.
- W2023486296 cites W2462655570 @default.
- W2023486296 cites W2187682547 @default.
- W2023486296 doi "https://doi.org/10.1159/000355767" @default.
- W2023486296 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24732082" @default.
- W2023486296 hasPublicationYear "2013" @default.
- W2023486296 type Work @default.
- W2023486296 sameAs 2023486296 @default.
- W2023486296 citedByCount "4" @default.
- W2023486296 countsByYear W20234862962015 @default.
- W2023486296 countsByYear W20234862962016 @default.
- W2023486296 countsByYear W20234862962018 @default.
- W2023486296 crossrefType "journal-article" @default.
- W2023486296 hasAuthorship W2023486296A5016295551 @default.
- W2023486296 hasAuthorship W2023486296A5025544794 @default.
- W2023486296 hasAuthorship W2023486296A5065631574 @default.
- W2023486296 hasBestOaLocation W20234862961 @default.
- W2023486296 hasConcept C126322002 @default.
- W2023486296 hasConcept C126894567 @default.
- W2023486296 hasConcept C134018914 @default.
- W2023486296 hasConcept C142225936 @default.
- W2023486296 hasConcept C159641895 @default.
- W2023486296 hasConcept C185592680 @default.
- W2023486296 hasConcept C20299238 @default.
- W2023486296 hasConcept C2778653478 @default.
- W2023486296 hasConcept C2779961880 @default.
- W2023486296 hasConcept C2780091579 @default.
- W2023486296 hasConcept C2780152017 @default.
- W2023486296 hasConcept C2780472472 @default.
- W2023486296 hasConcept C555293320 @default.
- W2023486296 hasConcept C71924100 @default.
- W2023486296 hasConcept C77411442 @default.
- W2023486296 hasConceptScore W2023486296C126322002 @default.
- W2023486296 hasConceptScore W2023486296C126894567 @default.
- W2023486296 hasConceptScore W2023486296C134018914 @default.
- W2023486296 hasConceptScore W2023486296C142225936 @default.
- W2023486296 hasConceptScore W2023486296C159641895 @default.
- W2023486296 hasConceptScore W2023486296C185592680 @default.
- W2023486296 hasConceptScore W2023486296C20299238 @default.
- W2023486296 hasConceptScore W2023486296C2778653478 @default.
- W2023486296 hasConceptScore W2023486296C2779961880 @default.
- W2023486296 hasConceptScore W2023486296C2780091579 @default.
- W2023486296 hasConceptScore W2023486296C2780152017 @default.
- W2023486296 hasConceptScore W2023486296C2780472472 @default.
- W2023486296 hasConceptScore W2023486296C555293320 @default.
- W2023486296 hasConceptScore W2023486296C71924100 @default.
- W2023486296 hasConceptScore W2023486296C77411442 @default.
- W2023486296 hasIssue "2-3" @default.
- W2023486296 hasLocation W20234862961 @default.
- W2023486296 hasLocation W20234862962 @default.
- W2023486296 hasOpenAccess W2023486296 @default.
- W2023486296 hasPrimaryLocation W20234862961 @default.
- W2023486296 hasRelatedWork W2023486296 @default.
- W2023486296 hasRelatedWork W2028361448 @default.
- W2023486296 hasRelatedWork W2046380573 @default.
- W2023486296 hasRelatedWork W2404152533 @default.
- W2023486296 hasRelatedWork W2532130872 @default.
- W2023486296 hasRelatedWork W3003790982 @default.
- W2023486296 hasRelatedWork W3010892901 @default.
- W2023486296 hasRelatedWork W3199424184 @default.