FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023486866> ?p ?o ?g. }

• W2023486866 endingPage "3358" @default.
• W2023486866 startingPage "3349" @default.
• W2023486866 abstract "Abstract The distribution of drug delivery systems into the body is affected by plasma proteins adsorbed onto their surface. Furthermore, an exact understanding of the structure and morphology of drug carriers is fundamental to understand their role as gene delivery systems. In this work, the adsorption of human plasma proteins bound to cationic liposomes and to their relative DNA lipoplexes was compared. A shotgun proteomics approach based on HPLC coupled to high resolution MS was used for an efficient identification of proteins adsorbed onto liposome and lipoplex surfaces. The distinct pattern of proteins adsorbed helps to better understand the DNA compaction process. The experimental evidence leads us to hypothesize that polyanionic DNA is associated to the lipoplex surface and can interact with basic plasma proteins. Such a finding is in agreement with recent results showing that lipoplexes are multilamellar DNA/lipid domains partially decorated with DNA at their surface. Proteomics experiments showed that the lipoplex corona is rich of biologically relevant proteins such as fibronectin, histones and complement proteins. Our results provide novel insights to understand how lipoplexes activate the immune system and why they are rapidly cleared from the blood stream. The differences in the protein adsorption data detected in the presented experiments could be the basis for the establishment of a correlation between protein adsorption pattern and in vivo fate of intravenously administered nanoparticles and will require some consideration in the future." @default.
• W2023486866 created "2016-06-24" @default.
• W2023486866 creator A5013516500 @default.
• W2023486866 creator A5014452034 @default.
• W2023486866 creator A5027072069 @default.
• W2023486866 creator A5040610833 @default.
• W2023486866 creator A5041582365 @default.
• W2023486866 creator A5045421567 @default.
• W2023486866 creator A5051147546 @default.
• W2023486866 date "2011-07-13" @default.
• W2023486866 modified "2023-10-18" @default.
• W2023486866 title "DNA affects the composition of lipoplex protein corona: A proteomics approach" @default.
• W2023486866 cites W1527888432 @default.
• W2023486866 cites W1540483167 @default.
• W2023486866 cites W1582366477 @default.
• W2023486866 cites W1973491891 @default.
• W2023486866 cites W1975528602 @default.
• W2023486866 cites W1985164864 @default.
• W2023486866 cites W1989329597 @default.
• W2023486866 cites W1990456103 @default.
• W2023486866 cites W1994455101 @default.
• W2023486866 cites W1995704440 @default.
• W2023486866 cites W2008058817 @default.
• W2023486866 cites W2014659193 @default.
• W2023486866 cites W2015556811 @default.
• W2023486866 cites W2021538200 @default.
• W2023486866 cites W2023124533 @default.
• W2023486866 cites W2029560804 @default.
• W2023486866 cites W2030384860 @default.
• W2023486866 cites W2038246612 @default.
• W2023486866 cites W2045101135 @default.
• W2023486866 cites W2049252345 @default.
• W2023486866 cites W2049979253 @default.
• W2023486866 cites W2057910069 @default.
• W2023486866 cites W2065629759 @default.
• W2023486866 cites W2094591392 @default.
• W2023486866 cites W2099856941 @default.
• W2023486866 cites W2112078820 @default.
• W2023486866 cites W2117318887 @default.
• W2023486866 cites W2125123295 @default.
• W2023486866 cites W2132899146 @default.
• W2023486866 cites W2136756539 @default.
• W2023486866 cites W2158138220 @default.
• W2023486866 cites W2158204011 @default.
• W2023486866 cites W2162710106 @default.
• W2023486866 cites W2166090214 @default.
• W2023486866 cites W2170085660 @default.
• W2023486866 cites W2172116519 @default.
• W2023486866 cites W2315102725 @default.
• W2023486866 cites W2325885736 @default.
• W2023486866 cites W4313333726 @default.
• W2023486866 doi "https://doi.org/10.1002/pmic.201000803" @default.
• W2023486866 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21751361" @default.
• W2023486866 hasPublicationYear "2011" @default.
• W2023486866 type Work @default.
• W2023486866 sameAs 2023486866 @default.
• W2023486866 citedByCount "31" @default.
• W2023486866 countsByYear W20234868662012 @default.
• W2023486866 countsByYear W20234868662013 @default.
• W2023486866 countsByYear W20234868662014 @default.
• W2023486866 countsByYear W20234868662015 @default.
• W2023486866 countsByYear W20234868662016 @default.
• W2023486866 countsByYear W20234868662017 @default.
• W2023486866 countsByYear W20234868662019 @default.
• W2023486866 countsByYear W20234868662020 @default.
• W2023486866 countsByYear W20234868662021 @default.
• W2023486866 countsByYear W20234868662022 @default.
• W2023486866 countsByYear W20234868662023 @default.
• W2023486866 crossrefType "journal-article" @default.
• W2023486866 hasAuthorship W2023486866A5013516500 @default.
• W2023486866 hasAuthorship W2023486866A5014452034 @default.
• W2023486866 hasAuthorship W2023486866A5027072069 @default.
• W2023486866 hasAuthorship W2023486866A5040610833 @default.
• W2023486866 hasAuthorship W2023486866A5041582365 @default.
• W2023486866 hasAuthorship W2023486866A5045421567 @default.
• W2023486866 hasAuthorship W2023486866A5051147546 @default.
• W2023486866 hasConcept C104317684 @default.
• W2023486866 hasConcept C12554922 @default.
• W2023486866 hasConcept C155887181 @default.
• W2023486866 hasConcept C185154212 @default.
• W2023486866 hasConcept C185592680 @default.
• W2023486866 hasConcept C46111723 @default.
• W2023486866 hasConcept C54009773 @default.
• W2023486866 hasConcept C552990157 @default.
• W2023486866 hasConcept C55493867 @default.
• W2023486866 hasConcept C64927066 @default.
• W2023486866 hasConcept C70721500 @default.
• W2023486866 hasConcept C86803240 @default.
• W2023486866 hasConcept C95444343 @default.
• W2023486866 hasConceptScore W2023486866C104317684 @default.
• W2023486866 hasConceptScore W2023486866C12554922 @default.
• W2023486866 hasConceptScore W2023486866C155887181 @default.
• W2023486866 hasConceptScore W2023486866C185154212 @default.
• W2023486866 hasConceptScore W2023486866C185592680 @default.
• W2023486866 hasConceptScore W2023486866C46111723 @default.
• W2023486866 hasConceptScore W2023486866C54009773 @default.
• W2023486866 hasConceptScore W2023486866C552990157 @default.
• W2023486866 hasConceptScore W2023486866C55493867 @default.

• next