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- W2023488269 abstract "The Notch signaling pathway is critical in cell fate specification throughout development. In the developing wing disc, single sensory organ precursors (SOPs) are selected from proneural clusters via a process of lateral inhibition mediated by the Notch signaling pathway. The epidermal growth factor receptor (EGFR) pathway has also been implicated in SOP formation. Here, we describe the Drosophila melanogaster gene friend of echinoid (fred), a paralogue of echinoid (ed), a gene recently identified as a negative regulator of the EGFR pathway. fred function was examined in transgenic flies by using inducible RNA interference (RNAi). Suppression of fred in developing wing discs results in specification of ectopic SOPs, additional microchaeta, and cell death. In eye-antennal discs, fred suppression causes a rough eye phenotype. These phenotypes are suppressed by overexpression of Notch, Suppressor of Hairless [Su(H)], and Enhancer of split m7. In contrast, overexpression of Hairless, a negative regulator of the Notch pathway, and decreased Su(H) activity enhance these phenotypes. Thus, fred acts in close concert with the Notch signaling pathway. Dosage-sensitive genetic interaction also suggests a close relationship between fred and ed." @default.
- W2023488269 created "2016-06-24" @default.
- W2023488269 creator A5036878767 @default.
- W2023488269 creator A5046607623 @default.
- W2023488269 creator A5084935715 @default.
- W2023488269 date "2003-04-01" @default.
- W2023488269 modified "2023-09-30" @default.
- W2023488269 title "The Drosophila IgC2 domain protein friend-of-echinoid, a paralogue of echinoid, limits the number of sensory organ precursors in the wing disc and interacts with the Notch signaling pathway" @default.
- W2023488269 cites W1595935608 @default.
- W2023488269 cites W1675105744 @default.
- W2023488269 cites W1774630646 @default.
- W2023488269 cites W1790815665 @default.
- W2023488269 cites W1844615320 @default.
- W2023488269 cites W1858049339 @default.
- W2023488269 cites W1892778056 @default.
- W2023488269 cites W1970059183 @default.
- W2023488269 cites W1970180329 @default.
- W2023488269 cites W1970396586 @default.
- W2023488269 cites W1979879836 @default.
- W2023488269 cites W1981943299 @default.
- W2023488269 cites W1985456400 @default.
- W2023488269 cites W1996051858 @default.
- W2023488269 cites W1997955636 @default.
- W2023488269 cites W1999529317 @default.
- W2023488269 cites W2000550532 @default.
- W2023488269 cites W2002300136 @default.
- W2023488269 cites W2007769575 @default.
- W2023488269 cites W2010747656 @default.
- W2023488269 cites W2011868306 @default.
- W2023488269 cites W2013505425 @default.
- W2023488269 cites W2024475904 @default.
- W2023488269 cites W2031209863 @default.
- W2023488269 cites W2040634306 @default.
- W2023488269 cites W2041425399 @default.
- W2023488269 cites W2043408306 @default.
- W2023488269 cites W2047578520 @default.
- W2023488269 cites W2055043387 @default.
- W2023488269 cites W2055064474 @default.
- W2023488269 cites W2061416252 @default.
- W2023488269 cites W2062084323 @default.
- W2023488269 cites W2072158270 @default.
- W2023488269 cites W2073641852 @default.
- W2023488269 cites W2075947758 @default.
- W2023488269 cites W2078707642 @default.
- W2023488269 cites W2079790654 @default.
- W2023488269 cites W2083280774 @default.
- W2023488269 cites W2084896326 @default.
- W2023488269 cites W2084996914 @default.
- W2023488269 cites W2088539039 @default.
- W2023488269 cites W2091513322 @default.
- W2023488269 cites W2099032954 @default.
- W2023488269 cites W2103080800 @default.
- W2023488269 cites W2106073107 @default.
- W2023488269 cites W2107326083 @default.
- W2023488269 cites W2108490725 @default.
- W2023488269 cites W2116577449 @default.
- W2023488269 cites W2117936709 @default.
- W2023488269 cites W2125629996 @default.
- W2023488269 cites W2140636249 @default.
- W2023488269 cites W2141652419 @default.
- W2023488269 cites W2144868620 @default.
- W2023488269 cites W2149966287 @default.
- W2023488269 cites W2153838631 @default.
- W2023488269 cites W2154166273 @default.
- W2023488269 cites W2154861644 @default.
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- W2023488269 cites W2159334577 @default.
- W2023488269 cites W2159935247 @default.
- W2023488269 cites W2160265391 @default.
- W2023488269 cites W2164118416 @default.
- W2023488269 cites W2168144800 @default.
- W2023488269 cites W2168565154 @default.
- W2023488269 cites W2170231361 @default.
- W2023488269 cites W2181739110 @default.
- W2023488269 cites W2184311355 @default.
- W2023488269 cites W2184665519 @default.
- W2023488269 cites W2185580285 @default.
- W2023488269 cites W2406174348 @default.
- W2023488269 cites W4210958860 @default.
- W2023488269 cites W4246880018 @default.
- W2023488269 cites W48985497 @default.
- W2023488269 cites W63871071 @default.
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- W2023488269 doi "https://doi.org/10.1016/s0012-1606(03)00038-1" @default.
- W2023488269 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12679104" @default.
- W2023488269 hasPublicationYear "2003" @default.
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