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• W2023488867 abstract "In this study, the effects of scopolamine, an acetylcholine muscarinic receptor antagonist, and physostigmine, an acetylcholinesterase inhibitor, on the learning ability and memory of zebrafish were evaluated using a passive avoidance response test. The zebrafish were trained to stay in a dark compartment to avoid a weight dropping into an acryl shuttle chamber with a central sliding door. The crossing time was increased significantly, from 30.7 ± 40.8 s to 179.3 ± 27.3 s in the training session and 179.9 ± 28.0 s in the test session carried out 2 h later in the controls. When treatment with 200 μM scopolamine was administered for 1 h prior to the training session, the crossing time did not increase. The scopolamine-induced learning deficit was ameliorated by pretreatment with 20 μM physostigmine for 1 h prior to scopolamine treatment; the crossing time was similarly increased, as shown with the controls (60.9 ± 11.5 s, 130.9 ± 27.5 s, and 183.4 ± 26.6 s in the training session and 108.1 ± 23.9 s in the test session). When scopolamine treatment was administered after the training session, the crossing time in the test session was reduced significantly as compared to that noted in the third trial of the training session, which was also ameliorated by physostigmine pretreatment. These results show that scopolamine impairs both the acquisition of passive avoidance response and retention of the learned response, and that physostigmine rescues the amnesic effects of scopolamine in zebrafish." @default.
• W2023488867 created "2016-06-24" @default.
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• W2023488867 date "2010-06-01" @default.
• W2023488867 modified "2023-10-17" @default.
• W2023488867 title "Scopolamine-induced learning impairment reversed by physostigmine in zebrafish" @default.
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• W2023488867 doi "https://doi.org/10.1016/j.neures.2010.03.003" @default.
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