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- W2023489114 abstract "Abstract The response of 5-fluorouracil-grown Escheruchia coli to ultraviolet irradiation was found to depend on the concentration of the analogue present during preincubation. Low concentrations of 5-fluorouracil enhanced resistance to ultraviolet irradiation whereas higher concentrations reduced it. An attempt was made to study the mechanism of the 5-fluorouracil-induced resistance to ultraviolet irradiation. For this purpose the composition of the cells at the time of irradiation, the effect of reversing agents on survival, and the post-irradiation metabolism of 5-fluorouracil-pretreated bacteria was studied. The results obtained showed a correlation between the DNA content of a cell and its response to ultraviolet irradiation; they also indicate that 5-fluorouracil-pretreated cells become resistant to the action of ultraviolet light on DNA synthesis. The significance of these results is discussed." @default.
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- W2023489114 date "1962-05-01" @default.
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- W2023489114 title "The effect of ultraviolet irradiation on 5-fluorouracil-pretreated bacteria" @default.
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- W2023489114 doi "https://doi.org/10.1016/0006-3002(62)90853-3" @default.
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