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- W2023489148 abstract "Abstract Actin, arranged for example in stress fibres, provides a fundamental cytoskeletal framework function to all cell types. Notably, there is now mounting evidence that, in addition to cytoplasmic cytoskeletal regulation, actin treadmilling provides a signal modulating nuclear gene expression. In altering gene regulation, cytoplasmic and most likely also a nucleus-resident actin provides an additional (gene) regulatory twist to cell motility. So far, the transcription factor serum response factor (SRF) alongside its myocardin-related transcription factor (MRTF) cofactors has emerged as the main target of actin dynamics. In this review, we discuss the impact of actin signalling on nuclear gene expression in the nervous system, where the actin-MRTF-SRF module contributes to various processes including neuronal motility." @default.
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- W2023489148 date "2011-03-01" @default.
- W2023489148 modified "2023-09-28" @default.
- W2023489148 title "The cytoskeleton and nucleus: the role of actin as a modulator of neuronal gene expression" @default.
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- W2023489148 doi "https://doi.org/10.1007/s13295-010-0013-y" @default.
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