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• W2023489244 abstract "Piperine, the pungent alkaloid of black pepper, and several of its derivatives are modulators of γ-amino butyric acid type A (GABAA) receptors. Concomitantly, this natural product has also been reported to activate transient receptor potential vanilloid type 1 (TRPV1) receptors. We have developed a Heck cross-coupling reaction of conjugated dienamides enabling the rapid assembly of piperine derivatives containing a modified aromatic core. Upon assessment of a focussed compound library, key aromatic substituents were identified selectively affecting either the GABAA or the TRPV1 receptor." @default.
• W2023489244 created "2016-06-24" @default.
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• W2023489244 date "2015-01-01" @default.
• W2023489244 modified "2023-10-05" @default.
• W2023489244 title "Developing piperine towards TRPV1 and GABA_A receptor ligands – synthesis of piperine analogs via Heck-coupling of conjugated dienes" @default.
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• W2023489244 doi "https://doi.org/10.1039/c4ob02242d" @default.
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