FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023489889> ?p ?o ?g. }

• W2023489889 endingPage "138" @default.
• W2023489889 startingPage "127" @default.
• W2023489889 abstract "We have examined the effects of triiodothyronine (T3), in dose-response and time-course studies, on T3 receptor (T3R) α and β and glucocorticoid receptor (GR) mRNAs in rate pituitary GH3 cells, in parallel with T3 actions on expression of the growth hormone (GH) target gene. Modulatory influences of dexamethasone (dex) on T3 action were studied by treatment with dex before and during T3 treatment. T3 treatment (1–100 nM) for 24 h reduced T3R α mRNA, while the presence of dex (1 μM) enhanced the T3 effect on T3R α mRNA and induced T3 inhibition of T3R β mRNA. Stimulatory effects of T3 treatment on GH mRNA and release were seen in the face of inhibition of T3R mRNAs; these effects on GH were also enhanced by the presence of dex. T3 treatment for 24 h increased GR mRNA; this effect was inhibited by the presence of dex. We next examined the influence of dex on GR and T3R α and β mRNAs, in parallel with effects of dex on the prolactin (PRL) target gene. Modulatory influences of T3 on dex action were studied by treatment of cells with T3 before and during dex treatment. Treatment with dex (0.1–10 μM) for 24 h reduced GR mRNA, an action enhanced by the presence of T3 (100 nM). Dex treatment resulted in inhibition of PRL mRNA and release despite parallel inhibition of GR mRNA by dex; these effects were enhanced by the presence of T3. In contrast to actions on GR, dex has no effect on T3R mRNAs. These effects of T3 and dex on receptor mRNAs suggest that glucocorticoid modulation of T3 action is not related to direct actions on T3R synthesis. In contrast, the mechanism of T3 modulation of glucocorticoid action may be due in part to alteration of GR mRNA expression. Effects of T3 and dex on target gene expression were observed in the presence of parallel reduction of their respective receptor mRNAs. This provides new evidence that interactions between these hormones are likely to be mediated by mechanisms other than regulation of receptor gene expression." @default.
• W2023489889 created "2016-06-24" @default.
• W2023489889 creator A5049719396 @default.
• W2023489889 creator A5057139017 @default.
• W2023489889 creator A5076653057 @default.
• W2023489889 date "1991-09-01" @default.
• W2023489889 modified "2023-09-27" @default.
• W2023489889 title "Thyroid hormone and glucocorticoid regulation of receptor and target gene mRNAs in pituitary GH3 cells" @default.
• W2023489889 cites W123333279 @default.
• W2023489889 cites W1512062815 @default.
• W2023489889 cites W1514956241 @default.
• W2023489889 cites W1543106250 @default.
• W2023489889 cites W1568323065 @default.
• W2023489889 cites W1606138580 @default.
• W2023489889 cites W1749732282 @default.
• W2023489889 cites W1968649374 @default.
• W2023489889 cites W1977779461 @default.
• W2023489889 cites W1978701193 @default.
• W2023489889 cites W1982406908 @default.
• W2023489889 cites W1990675136 @default.
• W2023489889 cites W1992032967 @default.
• W2023489889 cites W1993162221 @default.
• W2023489889 cites W1994987671 @default.
• W2023489889 cites W2001491728 @default.
• W2023489889 cites W2002712696 @default.
• W2023489889 cites W2005330687 @default.
• W2023489889 cites W2007169317 @default.
• W2023489889 cites W2008130983 @default.
• W2023489889 cites W2011679875 @default.
• W2023489889 cites W2018737282 @default.
• W2023489889 cites W2025927263 @default.
• W2023489889 cites W2028549678 @default.
• W2023489889 cites W2030315227 @default.
• W2023489889 cites W2050874067 @default.
• W2023489889 cites W2060333964 @default.
• W2023489889 cites W2062788143 @default.
• W2023489889 cites W2071337848 @default.
• W2023489889 cites W2077580619 @default.
• W2023489889 cites W2077993951 @default.
• W2023489889 cites W2078724152 @default.
• W2023489889 cites W2080046379 @default.
• W2023489889 cites W2084444108 @default.
• W2023489889 cites W2085124463 @default.
• W2023489889 cites W2090024435 @default.
• W2023489889 cites W2100204438 @default.
• W2023489889 cites W2103759127 @default.
• W2023489889 cites W2104360623 @default.
• W2023489889 cites W2126534142 @default.
• W2023489889 cites W2129593577 @default.
• W2023489889 cites W2130826810 @default.
• W2023489889 cites W2132264591 @default.
• W2023489889 cites W2150342440 @default.
• W2023489889 cites W2160277752 @default.
• W2023489889 cites W2166401623 @default.
• W2023489889 cites W2171315857 @default.
• W2023489889 cites W2068452590 @default.
• W2023489889 doi "https://doi.org/10.1016/0303-7207(91)90149-m" @default.
• W2023489889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1955072" @default.
• W2023489889 hasPublicationYear "1991" @default.
• W2023489889 type Work @default.
• W2023489889 sameAs 2023489889 @default.
• W2023489889 citedByCount "25" @default.
• W2023489889 countsByYear W20234898892013 @default.
• W2023489889 countsByYear W20234898892023 @default.
• W2023489889 crossrefType "journal-article" @default.
• W2023489889 hasAuthorship W2023489889A5049719396 @default.
• W2023489889 hasAuthorship W2023489889A5057139017 @default.
• W2023489889 hasAuthorship W2023489889A5076653057 @default.
• W2023489889 hasConcept C104317684 @default.
• W2023489889 hasConcept C105580179 @default.
• W2023489889 hasConcept C109115496 @default.
• W2023489889 hasConcept C126322002 @default.
• W2023489889 hasConcept C134018914 @default.
• W2023489889 hasConcept C150194340 @default.
• W2023489889 hasConcept C170493617 @default.
• W2023489889 hasConcept C185592680 @default.
• W2023489889 hasConcept C2778288131 @default.
• W2023489889 hasConcept C2779064019 @default.
• W2023489889 hasConcept C2780401358 @default.
• W2023489889 hasConcept C2780841215 @default.
• W2023489889 hasConcept C526584372 @default.
• W2023489889 hasConcept C55493867 @default.
• W2023489889 hasConcept C59493245 @default.
• W2023489889 hasConcept C71315377 @default.
• W2023489889 hasConcept C71924100 @default.
• W2023489889 hasConcept C86803240 @default.
• W2023489889 hasConceptScore W2023489889C104317684 @default.
• W2023489889 hasConceptScore W2023489889C105580179 @default.
• W2023489889 hasConceptScore W2023489889C109115496 @default.
• W2023489889 hasConceptScore W2023489889C126322002 @default.
• W2023489889 hasConceptScore W2023489889C134018914 @default.
• W2023489889 hasConceptScore W2023489889C150194340 @default.
• W2023489889 hasConceptScore W2023489889C170493617 @default.
• W2023489889 hasConceptScore W2023489889C185592680 @default.
• W2023489889 hasConceptScore W2023489889C2778288131 @default.
• W2023489889 hasConceptScore W2023489889C2779064019 @default.
• W2023489889 hasConceptScore W2023489889C2780401358 @default.
• W2023489889 hasConceptScore W2023489889C2780841215 @default.

• next